File:Regulation of glycolysis and TCA cycle by HIF.jpg

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Description Regulation of glycolysis and TCA cycle (tricarboxylic acid cycle or citric acid cycle) by HIF. HIF-1 enhances aerobic glycolysis in the cytoplasm by which glucose is metabolized to lactate rather than converted to acetyl-CoA to undergo oxidative phosphorylation (OXPHOS) in mitochondria. HIF-1 stimulates the utilization of glutamine and fatty acids as alternative substrates for mitochondrial energy production. OXPHOS: oxidative phosphorylation, TCA cycle: tricarboxylic acid or Krebs cycle; ROS: reactive oxygen species, LDHA: lactate dehydrogenase A, IDH: Isocitrate dehydrogenase, FAD: Flavin adenine dinucleotide, FASN: fatty acid synthase, NAD: Nicotinamide adenine dinucleotide, PDH: pyruvate dehydrogenase; PDK1: pyruvate dehydrogenase kinase isozyme 1, PK-M2: pyruvate kinase muscle isozyme 2; PGK1: Phosphoglycerate kinase 1 HK1,2: Hexokinase-1,2
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Source https://www.researchgate.net/publication/331706360_Resistance_to_anoikis_in_transcoelomic_shedding_The_role_of_glycolytic_enzymes Resistance to anoikis in transcoelomic shedding: The role of glycolytic enzymes. Pleura and Peritoneum. 4. 10.1515/pp-2019-0003.
Author Wilson, Robert & Solass, Wiebke & Archid, Rami & Weinreich, Jürgen & Königsrainer, Alfred & Reymond, Marc.
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current13:58, 3 June 2024Thumbnail for version as of 13:58, 3 June 2024850 × 644 (780 KB)Rasbak (talk | contribs){{Information |description=Regulation of glycolysis and TCA (tricarboxylic acid) cycle by HIF. HIF-1 enhances aerobic glycolysis in the cytoplasm by which glucose is metabolized to lactate rather than converted to acetyl-CoA to undergo oxidative phosphorylation (OXPHOS) in mitochondria. HIF-1 stimulates the utilization of glutamine and fatty acids as alternative substrates for mitochondrial energy production. OXPHOS: oxidative phosphorylation, TCA cycle: tricarboxylic acid or Krebs cycle; ROS...

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