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{{short description|Influenza virus strain}}
{{Use dmy dates|date = June 2020}}
'''G4 EA H1N1''' is an [[influenza]] virus discovered in China, with evidence of initial infection having been found in people who work in abattoirs and the swine industry. A [[reassortment]] of an avian virus and two strains of [[H1N1]], it is related to [[A/H1N1pdm09]], the virus responsible for the [[2009 swine flu pandemic]],<ref>{{Cite journal|last=Sun|first=Honglei|last2=Xiao|first2=Yihong|last3=Liu|first3=Jiyu|last4=Wang|first4=Dayan|last5=Li|first5=Fangtao|last6=Wang|first6=Chenxi|last7=Li|first7=Chong|last8=Zhu|first8=Junda|last9=Song|first9=Jingwei|last10=Sun|first10=Haoran|last11=Jiang|first11=Zhimin|date=2020-06-24|title=Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection|url=https://www.pnas.org/content/early/2020/06/23/1921186117|journal=Proceedings of the National Academy of Sciences|language=en|doi=10.1073/pnas.1921186117|issn=0027-8424}}</ref> and is also related to the strain that caused the [[1918 flu pandemic]] as both are [[Influenza A virus subtype H1N1|H1N1]] flu strains. It mainly affects pigs, but two cases have been identified in humans. As of June 2020, it is not easily [[Human-to-human transmission|transmissible between humans]], but has "pandemic potential".<ref name="sciencemag20200629">{{Cite news|url= https://www.sciencemag.org/news/2020/06/swine-flu-strain-human-pandemic-potential-increasingly-found-chinese-pigs |title= Swine flu strain with human pandemic potential increasingly found in Chinese pigs |newspaper= Science |publisher= AAAS |date= 2020-06-29 |accessdate= 2020-06-30 }}</ref> It is in the second phase of the "WHO Pandemic Phase Descriptions" as only [[Zoonosis|Animal-to-Human Transmission]] has been confirmed.<ref>{{Cite web|last=Information|first=National Center for Biotechnology|last2=Pike|first2=U. S. National Library of Medicine 8600 Rockville|last3=MD|first3=Bethesda|last4=Usa|first4=20894|date=2009|title=TABLE 3, WHO PANDEMIC PHASE DESCRIPTIONS AND MAIN ACTIONS BY PHASE|url=https://www.ncbi.nlm.nih.gov/books/NBK143061/table/ch4.t1/|access-date=2020-06-30|website=www.ncbi.nlm.nih.gov|language=en}}</ref>
A [[peer review|peer-reviewed]] paper from the ''[[Proceedings of the National Academy of Sciences]]'' (''PNAS'') noted that "G4 EA H1N1 viruses possess all the essential hallmarks of being highly adapted to infect humans... Controlling the prevailing G4 EA H1N1 viruses in pigs and close monitoring of swine working populations should be promptly implemented."<ref>{{Cite journal|last=Sun|first=Honglei|last2=Xiao|first2=Yihong|last3=Liu|first3=Jiyu|last4=Wang|first4=Dayan|last5=Li|first5=Fangtao|last6=Wang|first6=Chenxi|last7=Li|first7=Chong|last8=Zhu|first8=Junda|last9=Song|first9=Jingwei|last10=Sun|first10=Haoran|last11=Jiang|first11=Zhimin|date=2020-06-24|title=Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection|url=https://www.pnas.org/content/early/2020/06/23/1921186117|journal=Proceedings of the National Academy of Sciences|language=en|doi=10.1073/pnas.1921186117|issn=0027-8424}}</ref> (The current monitoring program has taken nasal swaps of more than 30,000 swine over seven years.)<ref name="sciencemag20200629"/>
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