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Clark was a founding director and investor in the biotechnology company DNA Sciences, founded in 1998 to unravel the genetics of common disease using volunteers recruited from the Internet launched August 1, 2000 (see The New York Times). In 2003, the company was acquired by Genaissance Pharmaceuticals Inc.
Clark was the subject of the 1999 bestseller ''[[The New New Thing]]: A Silicon Valley Story'' by U.S. author [[Michael Lewis (author)|Michael Lewis]]. {{ISBN|0-340-76699-9}}<ref>[http://www.york.ac.uk/inst/greenchemcic/AboutUs/James.htm Professor James Clark Director of the Green Chemistry Centre of Excellence for Industry]. Green Chemistry Centre of Excellence, accessed December 30, 2010.</ref>
Clark was a notable investor in Kibu.com, an Internet website for teens, which received approximately $22 million in funding.<ref>{{Cite news|url=https://www.nytimes.com/2000/10/03/business/technology-briefing-internet-girls-site-closing.html|title=Girls site closing|last=Flynn|first=Laurie J.|date=October 3, 2000|work=New York Times|access-date=January 19, 2017|via=}}</ref> The website shut down in 2000, returning its remaining capital to investors.
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