Esafoxolaner/eprinomectin/praziquantel: Difference between revisions
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'''Esafoxolaner/eprinomectin/praziquantel''', sold under the brand name '''Nexgard Combo''', is a [[fixed-dose combination medication]] used for the treatment and control of flea infestations, ticks, ear mites, and infections caused by tapeworms and ''[[Toxocara cati]]''.<ref name="Nexgard Combo FDA label" /> It is also used for the prevention of heartworm disease ''[[Dirofilaria immitis]]''. It contains [[esafoxolaner]], an aryl [[isoxazoline]]; [[eprinomectin]], an [[avermectin]] [[anthelmintic]]; and [[praziquantel]], a [[pyrazinoisoquinoline]] anthelmintic.<ref name="Nexgard Combo FDA label" /> |
'''Esafoxolaner/eprinomectin/praziquantel''', sold under the brand name '''Nexgard Combo''', is a [[fixed-dose combination medication]] used for the treatment and control of flea infestations, ticks, ear mites, and infections caused by tapeworms and ''[[Toxocara cati]]''.<ref name="Nexgard Combo FDA label" /> It is also used for the prevention of heartworm disease ''[[Dirofilaria immitis]]''. It contains [[esafoxolaner]], an aryl [[isoxazoline]]; [[eprinomectin]], an [[avermectin]] [[anthelmintic]]; and [[praziquantel]], a [[pyrazinoisoquinoline]] anthelmintic.<ref name="Nexgard Combo FDA label" /> |
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== uses == |
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In the United States, esafoxolaner/eprinomectin/praziquantel is [[indicated]] for the prevention of heartworm disease caused by ''Dirofilaria immitis'' and for the treatment and control of roundworm (fourth stage larval and adult ''Toxocara cati''), hookworm (fourth stage larval and adult ''[[Ancylostoma tubaeforme]]''; adult ''[[Ancylostoma braziliense]]''), and tapeworm (''[[Dipylidium caninum]]'') infections.<ref name="NexGard Combo" /><ref name="NexGard Combo FOI" /> It kills adult fleas (''[[Ctenocephalides felis]]'') and is indicated for the treatment and prevention of flea infestations and the treatment and control of ''[[Ixodes scapularis]]'' (black-legged tick) and ''[[Amblyomma americanum]]'' (lone star tick) infestations for one month in cats and kittens eight weeks of age and older, and weighing {{convert|1.8|lb|kg}} or greater.<ref name="NexGard Combo">{{cite web | title=NexGard Combo 141-570 | website=U.S. Food and Drug Administration | url=https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141-570 | access-date=14 April 2024}} {{PD-notice}}</ref><ref name="NexGard Combo FOI">https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/13855</ref> |
In the United States, esafoxolaner/eprinomectin/praziquantel is [[indicated]] for the prevention of heartworm disease caused by ''Dirofilaria immitis'' and for the treatment and control of roundworm (fourth stage larval and adult ''Toxocara cati''), hookworm (fourth stage larval and adult ''[[Ancylostoma tubaeforme]]''; adult ''[[Ancylostoma braziliense]]''), and tapeworm (''[[Dipylidium caninum]]'') infections.<ref name="NexGard Combo" /><ref name="NexGard Combo FOI" /> It kills adult fleas (''[[Ctenocephalides felis]]'') and is indicated for the treatment and prevention of flea infestations and the treatment and control of ''[[Ixodes scapularis]]'' (black-legged tick) and ''[[Amblyomma americanum]]'' (lone star tick) infestations for one month in cats and kittens eight weeks of age and older, and weighing {{convert|1.8|lb|kg}} or greater.<ref name="NexGard Combo">{{cite web | title=NexGard Combo 141-570 | website=U.S. Food and Drug Administration | url=https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141-570 | access-date=14 April 2024}} {{PD-notice}}</ref><ref name="NexGard Combo FOI">https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/13855</ref> |
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== References == |
== References == |
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Revision as of 05:27, 8 July 2024
| Combination of | |
|---|---|
| Esafoxolaner | aryl isoxazoline |
| Eprinomectin | avermectin anthelmintic |
| Praziquantel | pyrazinoisoquinoline anthelmintic |
| Clinical data | |
| Trade names | Nexgard Combo |
| Routes of administration | Topical |
| ATC code | |
| Legal status | |
| Legal status | |
Esafoxolaner/eprinomectin/praziquantel, sold under the brand name Nexgard Combo, is a fixed-dose combination medication used for the treatment and control of flea infestations, ticks, ear mites, and infections caused by tapeworms and Toxocara cati in cats.[3][4] It is also used for the prevention of heartworm disease Dirofilaria immitis. It contains esafoxolaner, an aryl isoxazoline; eprinomectin, an avermectin anthelmintic; and praziquantel, a pyrazinoisoquinoline anthelmintic.[3]
Veterinary uses
In the United States, esafoxolaner/eprinomectin/praziquantel is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (fourth stage larval and adult Toxocara cati), hookworm (fourth stage larval and adult Ancylostoma tubaeforme; adult Ancylostoma braziliense), and tapeworm (Dipylidium caninum) infections.[5][6] It kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations and the treatment and control of Ixodes scapularis (black-legged tick) and Amblyomma americanum (lone star tick) infestations for one month in cats and kittens eight weeks of age and older, and weighing 1.8 pounds (0.82 kg) or greater.[5][6]
References
- ^ "Nexgard Combo Product information". Health Canada. 5 January 2022. Retrieved 14 April 2024.
- ^ "Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Retrieved 25 March 2024.
- ^ a b c "Nexgard Combo- esafoxolaner, eprinomectin, and praziquantel solution". DailyMed. 7 March 2024. Retrieved 14 April 2024.
- ^ Beugnet F (2021). "NexGard® Combo (esafoxolaner, eprinomectin, praziquantel), a new endectoparasiticide spot-on formulation for cats". Parasite. 28. Paris, France: E1. doi:10.1051/parasite/2021013. PMC 8019561. PMID 33812448.
- ^ a b "NexGard Combo 141-570". U.S. Food and Drug Administration. Retrieved 14 April 2024.
This article incorporates text from this source, which is in the public domain.
- ^ a b "NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) Cats". New Animal Drug Application. U.S. Food and Drug Administration. NADA 141-570.
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