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{{short description|Drug combination}}
{{Drugbox
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 387076861
| verifiedrevid =
⚫
| type = combo
| image = Niacinstr.png
| image = .
| width = 100px
⚫
| image2 = Lovastatin.png
| image2 = Lovastatin2DCSD.svg
⚫
| component1 = Niacin
| width2 = 200px
| class1 = n/a

| component2 = Lovastatin
<!--Combo data-->
⚫
| class2 = [[Statin]]
⚫
| type = combo
⚫
| CAS_number =
⚫
| component1 = Niacin
⚫
| ATC_prefix = C10
| class1 = [[Lipid-lowering agent]]
⚫
| ATC_suffix = BA01
⚫
| = Lovastatin
⚫
| PubChem =
⚫
| class2 = [[Statin]]
⚫
| DrugBank =

| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
<!--Clinical data-->
⚫
| pregnancy_US = X
| pregnancy_category=
| =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| = <!-- / / / / / / -->
⚫
| pregnancy_US = X
⚫
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| pregnancy_category =
⚫
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
⚫
| legal_US = Rx-only
⚫
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫
| legal_status =
⚫
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
⚫
| legal_US = Rx-only
⚫
| legal_status
| routes_of_administration = Oral
| routes_of_administration = Oral

<!--Identifiers-->
⚫
| CAS_number
⚫
| ATC_prefix = C10
⚫
| ATC_suffix = BA01
⚫
| PubChem
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
⚫
| DrugBank
| KEGG_Ref = {{keggcite|changed|kegg}}
| KEGG = D10292

<!--Chemical data-->
}}
}}


'''Niacin/lovastatin''' (trade names '''Advicor''', '''Mevacor''') is a drug combination used for the treatment of [[dyslipidemia]]. It is a combination of [[niacin]] and the [[statin]] drug [[lovastatin]]. The combination preparation is marketed by [[Abbott Laboratories]]
'''Niacin/lovastatin''' (trade names '''Advicor''') a drug combination used for the treatment of [[dyslipidemia]]. It a combination of [[niacin]] and the [[statin]] drug [[lovastatin]]. The combination preparation by [[Abbott Laboratories]]


Advicor was approved by the U.S. Food and Drug Administration (FDA) on December 17, 2001.<ref>{{cite web |url=https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/21-249_Advicor.cfm |title=Advicor (Niacin Extended-Release & Lovastatin) Tablets |date= 13 September 2002 |website=U.S. Food and Drug Administration; Drug Approval Package|access-date=17 May 2020}}</ref> The FDA withdrew approval on 18 April 2016. The reason given: "Based on the collective evidence from several large cardiovascular outcome trials (Refs. 1-3.), the Agency has concluded that the totality of the scientific evidence no longer supports the conclusion that a drug-induced reduction in triglyceride levels and/or increase in HDL-cholesterol levels in statin-treated patients results in a reduction in the risk of cardiovascular events." AbbVie Inc. agreed to voluntarily discontinue marketing Advicor.<ref name=FDAWithdrawal>{{cite web |url=https://www.federalregister.gov/documents/2016/04/18/2016-08894/abbvie-inc-withdrawal-of-approval-of-new-drug-applications-for-advicor-and-simcor |title=AbbVie Inc.; Withdrawal of Approval of New Drug Applications for ADVICOR and SIMCOR |date= 18 April 2016 |website=U.S. Federal Register|access-date=17 May 2020}}</ref> The same FDA action also applied to [[Niacin/simvastatin|Simcor]], a niacin-extended release combination with simvastatin.<ref name=FDAWithdrawal/>
It was approved by the FDA on December 17, 2001.


==Dosage==
==Dosage==
The combination is available as tablets containing:.<ref>{{cite web |url=http://www.rxlist.com/cgi/generic/advicor_ids.htm |title=Advicor package insert, How Supplied section |accessdate=2008-03-15 |format= |work= }}</ref>
The combination available as tablets containing :
* 500 mg/20 mg
* 500mg/20mg
* 750 mg/20 mg
* 750mg/20mg
* 1000 mg/20 mg
* 1000mg/20mg
* 1000 mg/40 mg
* 1000mg/40mg


==References==
==References==
{{Reflist}}
{{Reflist}}

==External links==
* [http://www.advicor.com Advicor] website


{{Statins}}
{{Statins}}


{{DEFAULTSORT:Niacin lovastatin}}

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[[Category:Combination drugs]]

[[Category:Drugs developed by AbbVie]]
{{cardiovascular-drug-stub}}

[[Category:Hypolipidemic agents]]
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[[Category:Combination drugs]]
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