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{{Short description|Pain medication}}
{{Globalize/USA|date=February 2011}}
{{Redirect2|Percocet|Percs|the band|Percocettes|the supercomputer technology|PERCS|the cleaning chemical PERC|tetrachloroethylene| the wrestler nicknamed "Perc Angle" |Kurt Angle}}
{{Use dmy dates|date=October 2022}}
{{cs1 config |name-list-style=vanc |display-authors=6}}
{{Drugbox
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 455186406
| Watchedfields = changed
| drug_name = Percocet
| verifiedrevid = 455187452
| type = combo
| image =
| alt =
| caption =


<!--Combo data-->
<!--Combo data-->
| component1 = Oxycodone
| type = combo
| class1 = [[Opioid|Opioid analgesic]]
| component1 = Oxycodone
| component2 = Acetaminophen
| class1 = [[Opioid|Opioid analgesic]]
| class2 = [[Anilides|Anilide analgesic]]
| component2 = Paracetamol
| class2 = [[Anilides|Anilide analgesic]]


<!--Clinical data-->
<!--Clinical data-->
| tradename =
| tradename =
| Drugs.com = {{drugs.com|monograph|oxycodone}}
| Drugs.com = {{drugs.com||oxycodone}}
| MedlinePlus =
| licence_EU = <!-- EMEA requires brand name -->
| DailyMedID = Oxycodone hydrochloride and acetaminophen
| licence_US = Percocet
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_category =
| pregnancy_US = <!-- A / B / C / D / X -->
| routes_of_administration = [[Oral administration|By mouth]]
| pregnancy_category = C
| ATC_prefix = N02
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| ATC_suffix = AJ17
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->

| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
<!-- Legal status -->
| legal_US = Schedule II
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| routes_of_administration = [[Mouth|Oral]]
| legal_AU_comment =
| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment =
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment =
| legal_DE = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment =
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment =
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment =
| legal_US = Schedule II
| legal_US_comment = <ref name="Percocet FDA label">{{cite web | title=Percocet- oxycodone hydrochloride and acetaminophen tablet | website=DailyMed | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4dd36cf5-8f73-404a-8b1d-3bd53bd90c25 | access-date=17 October 2021}}</ref>
| legal_EU =
| legal_EU_comment =
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment =
| legal_status = <!-- For countries not listed above -->


<!--Identifiers-->
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 330988-72-2
| CAS_number = 330988-72-2
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| DrugBank =
| StdInChI = 1S/C18H21NO4.C8H9NO2.ClH/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10;1-6(10)9-7-2-4-8(11)5-3-7;/h3-4,13,16,21H,5-9H2,1-2H3;2-5,11H,1H3,(H,9,10);1H/t13-,16+,17+,18-;;/m1../s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| = {{|correct|chemspider}}
| ChemSpiderID = 4881971
| StdInChIKey = LPIDDOOVLLQTPE-PCHTVJFHSA-N
| KEGG = D02153
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4881971

<!--Chemical data-->
}}
}}
The combination '''[[oxycodone]]/[[paracetamol]]''' (North American trade name of combination '''Percocet''', North American trade name of latter '''Acetaminophen''') is a [[narcotic]] pain reliever used to treat moderate to severe [[Acute (medical)|acute]] (short-term) [[pain]], marketed by [[Endo Pharmaceuticals]].<ref>http://www.endo.com/pdf/products/Percocet_pack_insert_2.pdf</ref>


'''Oxycodone/paracetamol''',<!-- NOTE: DO NOT CHANGE TO ACETAMINOPHEN, per [[WP:TITLE]] --> sold under the brand name '''Percocet''' among others, is a [[fixed-dose combination]] of the opioid [[oxycodone]] with [[paracetamol]] (acetaminophen), used to treat moderate to severe [[pain]].<ref name="Percocet FDA label" />
==History==
The [[U.S. Food and Drug Administration]] first approved Percocet in 1976, under application ANDA 085106.<ref>{{cite web|title=Drugs@FDA. FDA approved drug products (searchable database)|publisher=U.S. Food and Drug Administration, Center for Drug Evaluation and Research|url=http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm|accessdate=2009-03-30}}</ref>


In 2021, it was the 75th most commonly prescribed medication in the [[United States]], with more than 8{{nbsp}}million prescriptions.<ref>{{cite web | title=The Top 300 of 2021 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=14 January 2024 | archive-date=15 January 2024 | archive-url=https://web.archive.org/web/20240115223848/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Acetaminophen; Oxycodone - Drug Usage Statistics | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/AcetaminophenOxycodone | access-date = 14 January 2024}}</ref>
==Formulation==
As of March 2006, [[Endo Pharmaceuticals]] produces Percocet in following dosages.<ref name=insert>{{cite web|title=Percocet oxycodone and acetaminophen tablets USP|publisher=Endo Pharmaceuticals|date=2006 November|url=http://www.endo.com/pdf/products/Percocet_pack_insert_4.pdf|accessdate=2009-03-30}}</ref> Percocet [[tablet]]s are available in six combinations of oxycodone hydrochloride and [[acetaminophen]], with different appearances and maximum daily [[Dose (biochemistry)|dose]]s:<ref name=insert/>


==History==
{| class="wikitable" style="text-align:center"
The United States [[Food and Drug Administration]] (FDA) first approved Percocet in 1976, under application ANDA 085106.<ref>{{cite web | title=Percocet: FDA-Approved Drugs | website=U.S. [[Food and Drug Administration]] (FDA) | url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=085106 | access-date=17 October 2021}}</ref>
! Oxycodone Hydrochloride (mg) !! Acetaminophen (mg) !! Tablet Color !! Tablet Shape !! Maximum Daily Dose
|-
| 2.5 || 325 || pink || oval || 12 tablets
|-
| 5 || 325 || white || round || 12 tablets
|-
| 7.5 || 325 || peach || oval || 8 tablets
|-
| 7.5 || 500 || peach || capsule-shaped || 8 tablets
|-
| 10.0 || 325 || white || oblong || 6 tablets
|-
| 10.0 || 650 || yellow || oval || 6 tablets
|}


== Society and culture ==
For the 2.5&nbsp;mg Oxycodone HCL tablet, the usual dose is 1–2 tablets every six hours as needed for pain; for the other tablets, the usual dose is 1 tablet every six hours as needed for pain.<ref name=insert/>
=== Implicated in deaths ===
In June 2009, an FDA advisory panel recommended that Percocet, [[Vicodin]], and every other combination of acetaminophen with [[narcotic]] [[analgesics]]<ref>{{cite web|url=http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen|title=FDA May Restrict Acetaminophen|work=WebMD}}</ref> be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to [[acetaminophen overdose]] and associated liver damage.<ref>{{cite news| url=https://www.nytimes.com/2009/07/01/health/01fda.html | work=[[The New York Times]] | title=Ban Is Advised on 2 Top Pills for Pain Relief | first=Gardiner | last=Harris | date=30 June 2009 | access-date=22 May 2010}}</ref>


In December 2009, the ''[[Canadian Medical Association Journal]]'' reported a study finding a fivefold increase in oxycodone-related deaths in [[Ontario]] (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.<ref>{{cite journal | vauthors = Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN | title = Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone | journal = CMAJ | volume = 181 | issue = 12 | pages = 891–6 | date = December 2009 | pmid = 19969578 | pmc = 2789126 | doi = 10.1503/cmaj.090784 }}</ref><ref>{{cite journal | vauthors = Fischer B, Rehm J | title = Deaths related to the use of prescription opioids | journal = CMAJ | volume = 181 | issue = 12 | pages = 881–2 | date = December 2009 | pmid = 19969577 | pmc = 2789122 | doi = 10.1503/cmaj.091791 }}</ref><ref>{{cite journal|journal=Canadian Medical Association Journal |date=7 December 2009 |title=Deaths from opioid use have doubled; five-fold increase in oxycodone deaths |access-date=31 May 2012 |url=https://www.sciencedaily.com/releases/2009/12/091207123105.htm}}</ref>
==Use in pain management==
This medicine, in recent years, has gained favor among the medical community due to its effectiveness and a lower addiction rate than [[morphine]]. It is very useful to give to someone who is experiencing acute severe pain that is neither [[Chronic pain|chronic]] nor [[Pain#Breakthrough_pain|breakthrough]].{{Citation needed|date=February 2010}}


In March 2017, US President [[Donald Trump]] initiated the [[Opioid and Drug Abuse Commission]].<ref>{{cite web|url=https://www.whitehouse.gov/the-press-office/2017/03/30/presidential-executive-order-establishing-presidents-commission|archive-url=https://web.archive.org/web/20170330193850/https://www.whitehouse.gov/the-press-office/2017/03/30/presidential-executive-order-establishing-presidents-commission|url-status=dead|archive-date=30 March 2017|title=Presidential Executive Order Establishing the President's Commission on Combating Drug Addiction and the Opioid Crisis|date=29 March 2017}}</ref> In July 2017, a draft report was published.<ref>{{cite web|url=https://trumpwhitehouse.archives.gov/sites/whitehouse.gov/files/ondcp/commission-interim-report.pdf|work=[[The White House]]|title=Draft interim report}}</ref>
==Implicated in deaths==
On June 30, 2009, an FDA advisory panel recommended that Percocet, [[Vicodin]], and every other combination of acetaminophen with [[narcotic]] [[analgesics]]<ref>http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen</ref> be removed from the market because of their contributions to an alleged 400 acetaminophen related deaths in the United States each year, that were attributed to [[Paracetamol toxicity|acetaminophen overdose]] and associated liver damage.<ref>{{cite news| url=http://www.nytimes.com/2009/07/01/health/01fda.html?em | work=The New York Times | title=Ban Is Advised on 2 Top Pills for Pain Relief | first=Gardiner | last=Harris | date=2009-07-01 | accessdate=2010-05-22}}</ref>


== References ==
In December 2009, the ''[[Canadian Medical Association Journal]]'' reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related Ontario deaths over the same period.<ref>[http://www.sciencedaily.com/releases/2009/12/091207123105.htm sciencedaily.com]</ref>

==References==
{{Reflist}}
{{Reflist}}


{{Analgesics}}
== External links==
{{Anti-inflammatory products}}
* [http://druginfo.nlm.nih.gov/drugportal/dpdirect.jsp?name=Acetaminophen+mixture+with+Oxycodone U.S. National Library of Medicine: Drug Information Portal - Percocet]
{{Opioidergics}}

{{Drug use}}
{{DEFAULTSORT:Oxycodone/Paracetamol}}
{{Portal bar | Medicine}}
[[Category:Analgesics]]
{{Authority control}}
[[Category:Combination drugs]]



{{DEFAULTSORT:Oxycodone Paracetamol}}
{{analgesic-stub}}
[[Category:Combination analgesics]]
[[Category:Hepatotoxins]]
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