Balofloxacin

Balofloxacin
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid;
CAS Number	127294-70-6 ;
PubChem CID	65958;
ChemSpider	59361 ;
UNII	Q022B63JPM;
ChEMBL	ChEMBL1210954 ;
CompTox Dashboard (EPA)	DTXSID5046695 ;
Chemical and physical data
Formula	C20H24FN3O4
Molar mass	389.427 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F;
	InChI InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27) ; Key:MGQLHRYJBWGORO-UHFFFAOYSA-N ;
	(what is this?) (verify)

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Balofloxacin (INN) is a fluoroquinolone antibiotic. It is sold under the brand name Q-Roxin in Korea, and under various names in India.^[1] It is not approved by the FDA for use in the United States.

Pharmacodynamics

Balofloxacin is a fluoroquinolone that has a broad spectrum in vitro activity against a wide range of Gram-positive and Gram-negative bacteria, with enhanced activity against Gram positive bacteria, including MRSA and Streptococcus pneumoniae.^[2] It functions by inhibiting the action of DNA-gyrase, preventing bacterial cells from reproducing or repairing themselves, resulting in cellular death.^[3]

Side Effects

Vomiting, headache, dizziness, stomach pain, nausea, diarrhea and decreased liver function are the most common side effects. In rare cases, Balofloxacin can lead to or worsen tendinitis,^[3] and muscular damage.^[3]

References

^ Alksne L (February 2003). "Balofloxacin Choongwae". Current Opinion in Investigational Drugs. 4 (2): 224–9. PMID 12669387.
^ "NCATS Inxight Drugs — BALOFLOXACIN". drugs.ncats.io. Retrieved 2022-07-28.
^ ^a ^b ^c "BALOFLOXACINhome: Uses, Side Effects and Medicines | Apollo Pharmacy". www.apollopharmacy.in. Retrieved 2022-07-28.

This systemic antibiotic-related article is a stub. You can help Wikipedia by expanding it.

[1] Alksne L (February 2003). "Balofloxacin Choongwae". Current Opinion in Investigational Drugs. 4 (2): 224–9. PMID 12669387.

[2] "NCATS Inxight Drugs — BALOFLOXACIN". drugs.ncats.io. Retrieved 2022-07-28.

[:1-3] "BALOFLOXACINhome: Uses, Side Effects and Medicines | Apollo Pharmacy". www.apollopharmacy.in. Retrieved 2022-07-28.

[1]

Pharmacodynamics

Side Effects

See also

References