HSD17B14

HSD17B14
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1YDE, 5ICS, 5ICM, 5JS6, 5HS6, 5JSF
Identifiers
Aliases	HSD17B14, DHRS10, SDR47C1, retSDR3, hydroxysteroid (17-beta) dehydrogenase 14, hydroxysteroid 17-beta dehydrogenase 14
External IDs	OMIM: 612832; MGI: 1913315; HomoloGene: 133800; GeneCards: HSD17B14; OMA:HSD17B14 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,836,510 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,217,176 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right adrenal cortex; ; right lobe of liver; ; left ovary; ; left adrenal cortex; ; nucleus accumbens; ; testicle; ; right ovary; ; right hemisphere of cerebellum; ; caudate nucleus;
	Top expressed in
	morula; ; blastocyst; ; lip; ; transitional epithelium of urinary bladder; ; embryo; ; muscle of thigh; ; esophagus; ; gastrula; ; blood; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; protein binding; testosterone 17-beta-dehydrogenase (NADP+) activity; identical protein binding; estradiol 17-beta-dehydrogenase activity;
Cellular component	cytoplasm; cytosol;
Biological process	steroid metabolic process; steroid catabolic process; lipid metabolism; estrogen biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	51171
	66065
	ENSG00000087076
	ENSMUSG00000030825
	Q9BPX1
	n/a
	NM_016246
	NM_025330
	NP_057330
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

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17β-Hydroxysteroid dehydrogenase type 14 also known as 17β-HSD type 14 or 17βHSD14 is an enzyme that in humans is encoded by the HSD17B14 gene.^[5]^[6]

17βHSD14 catalyzes the stereospecific oxidation and reduction of the 17β carbon atom of androgens and estrogens using NAD(P)(H) as a cofactor. It is primarily expressed in glandular epithelial tissues of breast, ovary, and testis.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087076 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030825 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhu YS, Imperato-McGinley JL (9 November 2016). "4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition". In Lightman S (ed.). Hormones, Brain and Behavior. Vol. 4: Clinical Important Effects of Hormones on Brain and Behavior. Elsevier Science. p. 69. ISBN 978-0-12-803608-2.
^ Zanders ED (9 November 2015). Human Drug Targets: A Compendium for Pharmaceutical Discovery. John Wiley & Sons. pp. 257–. ISBN 978-1-118-84985-9.
^ Sivik T, Vikingsson S, Gréen H, Jansson A (2012). "Expression patterns of 17β-hydroxysteroid dehydrogenase 14 in human tissues". Hormone and Metabolic Research. 44 (13): 949–56. doi:10.1055/s-0032-1321815. PMID 22864907. S2CID 557122.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087076 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030825 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Elsevier2016-5] Zhu YS, Imperato-McGinley JL (9 November 2016). "4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition". In Lightman S (ed.). Hormones, Brain and Behavior. Vol. 4: Clinical Important Effects of Hormones on Brain and Behavior. Elsevier Science. p. 69. ISBN 978-0-12-803608-2.

[Zanders2015-6] Zanders ED (9 November 2015). Human Drug Targets: A Compendium for Pharmaceutical Discovery. John Wiley & Sons. pp. 257–. ISBN 978-1-118-84985-9.

[pmid22864907-7] Sivik T, Vikingsson S, Gréen H, Jansson A (2012). "Expression patterns of 17β-hydroxysteroid dehydrogenase 14 in human tissues". Hormone and Metabolic Research. 44 (13): 949–56. doi:10.1055/s-0032-1321815. PMID 22864907. S2CID 557122.

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