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Biochemistry news
Discovery of a tRNA modification enzyme that also acts on nucleosides
The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating ...
Biochemistry
Jul 18, 2024
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De-risking drug discovery with predictive AI
Developing a new drug can take years of research and cost millions of dollars. Still, more than 90% of drug candidates fail in clinical trials, with even more that never make it to the clinical stage. Many drugs fail because ...
Biochemistry
Jul 18, 2024
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Scientists replicate enzyme that captures carbon
Scientists from King's College London have recreated the active site of Acetyl-CoA Synthase, an enzyme involved in capturing carbon from the atmosphere. The research, carried out in collaboration with Imperial College London, ...
Biochemistry
Jul 18, 2024
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Scientists develop fridge-free storage approach for vital medicines
Scientists have developed a new approach to store and distribute crucial protein therapeutics without the need for fridges or freezers.
Biochemistry
Jul 17, 2024
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Research team develops method to design safer opioids
Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose. In a study appearing in ACS Central ...
Biochemistry
Jul 17, 2024
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Light-activated system enables controlled antigen release for analysis of antigen processing
The immune system is always on alert, detecting and eliminating pathogens and cancer cells. Cellular control mechanisms cause diseased cells to present antigens on their surface like signs for the immune system.
Biochemistry
Jul 16, 2024
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Interdisciplinary approach provides new insights into molecular mechanisms of cholera infection
Cholera infections caused by Vibrio cholerae bacteria can be life-threatening and the trigger is the cholera toxin produced by the bacteria. It binds to the surface of intestinal cells—more precisely, to certain "sugar ...
Biochemistry
Jul 15, 2024
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Research team develops light-activated compounds to treat neuropathic pain
Light can be used to activate drugs in specific parts of the body through photopharmacology. This innovative approach involves modifying the chemical structure of a drug by adding a light-activated molecular switch, such ...
Biochemistry
Jul 12, 2024
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How to make an old antibiotic 100 times more potent
Nathaniel Martin, Professor of biological chemistry, wondered what would happen if you took an antibiotic that has been known for 70 years and tried to improve it with the latest tools of modern chemistry. Turns out it can ...
Biochemistry
Jul 12, 2024
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A comprehensive derivative synthesis method for development of new antimicrobial drugs
Efforts to combat the increasing threat of drug-resistant bacteria are being assisted by a new approach for streamlining the search for antimicrobial drug candidates, pioneered by researchers at Hokkaido University, led by ...
Biochemistry
Jul 12, 2024
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Nanoplastics and 'forever chemicals' shown to disrupt molecular structures and functionality
Researchers at The University of Texas at El Paso have made significant inroads in understanding how nanoplastics and per- and polyfluoroalkyl substances (PFAS)—commonly known as forever chemicals—disrupt biomolecular ...
Biochemistry
Jul 11, 2024
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One-step synthesis of pharmaceutical building blocks: New method for anti-Michael reaction
In 1887, chemist Sir Arthur Michael reported a nucleophilic addition reaction to the β-position of α,β- unsaturated carbonyl compounds. These reactions, named Michael addition reactions, have been extensively studied to ...
Biochemistry
Jul 11, 2024
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Densely packed E. coli form an immobile material similar to colloidal glass, research shows
Dense E. coli bacteria have several similar qualities to colloidal glass, according to new research at the University of Tokyo. Colloids are substances made up of small particles suspended within a fluid, like ink for example. ...
Biochemistry
Jul 11, 2024
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Researchers claim photoluminescent aerogel has a visible light reflectance of 104%
A team of chemists and materials scientists at Sichuan University, in China, has developed a photoluminescent aerogel with a visible light reflectance of 104%. In their study, published in the journal Science, the group created ...
Photoenzymatic synthesis achieves efficient oxidation of fatty acids
A research team designed and built a photoenzymatic cascade by combining photochemical water oxidation/O2 reduction with P450 peroxygenase catalysis to achieve efficient visible-light-driven oxidation of a range of fatty ...
Biochemistry
Jul 8, 2024
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First set of rational design principles for chaotropic membrane transporters
The challenge of internalizing impermeable molecules into cells persists in drug development, particularly concerning water-soluble bioactive compounds that cannot diffuse across the cell membrane. To overcome this problem, ...
Biochemistry
Jul 8, 2024
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Novel compound offers improved defense against fentanyl overdoses
Scientists at the University of Florida have identified a novel compound aimed at improving the treatment of opioid overdoses, which claimed the lives of more than 81,000 Americans last year.
Biochemistry
Jul 8, 2024
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Scientists sustainably create peptide-based medicines, pave way for greener cancer treatments
Scientists from the University of Manchester have uncovered a more efficient and sustainable way to make peptide-based medicines, showing promising effectiveness in combating cancers.
Biochemistry
Jul 8, 2024
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New probe reveals water-ice microstructures
Ice is believed to have played a crucial role in the emergence of life. One reason is that organic molecules can be excluded into the gaps between the crystal lattice by orderly arranged water molecules, leading to the concentration ...
Biochemistry
Jul 5, 2024
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AI approach optimizes development of antibody drugs
Proteins have evolved to excel at everything from contracting muscles to digesting food to recognizing viruses. To engineer better proteins, including antibodies, scientists often iteratively mutate the amino acids—the ...
Biochemistry
Jul 5, 2024
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Other news
Study deciphers intricate 3D structure of DNA aptamer for disease theranostics
Gold co-catalyst improves photocatalytic degradation of micropollutants, finds study
A new way to control the magnetic properties of rare earth elements
Chemists design novel method for generating sustainable fuel
New tractor beam technology could one day minimize biopsy trauma
Chemists develop a stable reagent for carbon-atom transfer
Mantle upwelling may have triggered Morocco earthquake
