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Comparative Study
. 2010 Mar 1;93(4):1333-7.
doi: 10.1016/j.fertnstert.2008.11.010. Epub 2009 Jan 9.

Prospective cohort study of three- versus two-dimensional ultrasound for prediction of oocyte maturity

Doron Shmorgun  1 , Edward Hughes, Patrick Mohide, Robin Roberts
Affiliations
Free article
Comparative Study

Prospective cohort study of three- versus two-dimensional ultrasound for prediction of oocyte maturity

Doron Shmorgun et al. Fertil Steril. .
Free article

Abstract

Objective: To determine whether three-dimensional follicular ultrasound (3-D) measurements are better predictors of optimal timing of hCG administration than two-dimensional (2-D) images, the current standard.

Design: Prospective, cohort study.

Setting: Tertiary referral center.

Patient(s): Seventy-six patients undergoing IVF.

Intervention(s): Seventy-six consecutive patients undergoing serial follicular monitoring during IVF had an additional daily 3-D volume scan of their ovaries once lead follicles had reached 16 mm diameter.

Main outcome measure(s): Number of mature oocytes retrieved.

Result(s): The 2-D follicular diameter measurements predicted 25.4% of the observed variance in the number of mature oocytes retrieved. The 3-D follicular volume measurements were more predictive of outcome, accounting for 29.2% of the observed variance in number of mature oocytes retrieved. Follicles >22 mm diameter and 5 mL volume were associated with fewer mature oocytes reflecting an undesired postmature state. Follicles measuring 11 to 15 mm had a 50% chance of yielding a mature oocyte.

Conclusion(s): Three-dimensional follicular volume measurements have a stronger correlation with the number of mature oocytes retrieved than 2-D measurements. As 3-D technology improves, this parameter may replace 2-D measurements in the optimal timing of hCG before oocyte retrieval.

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