Application of Stem Cell Therapy for Infertility
- PMID: 34203240
- PMCID: PMC8303590
- DOI: 10.3390/cells10071613
Application of Stem Cell Therapy for Infertility
Abstract
Infertility creates an immense impact on the psychosocial wellbeing of affected couples, leading to poor quality of life. Infertility is now considered to be a global health issue affecting approximately 15% of couples worldwide. It may arise from factors related to the male (30%), including varicocele, undescended testes, testicular cancer, and azoospermia; the female (30%), including premature ovarian failure and uterine disorders; or both partners (30%). With the recent advancement in assisted reproduction technology (ART), many affected couples (80%) could find a solution. However, a substantial number of couples cannot conceive even after ART. Stem cells are now increasingly being investigated as promising alternative therapeutics in translational research of regenerative medicine. Tremendous headway has been made to understand the biology and function of stem cells. Considering the minimum ethical concern and easily available abundant resources, extensive research is being conducted on induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSC) for their potential application in reproductive medicine, especially in cases of infertility resulting from azoospermia and premature ovarian insufficiency. However, most of these investigations have been carried out in animal models. Evolutionary divergence observed in pluripotency among animals and humans requires caution when extrapolating the data obtained from murine models to safely apply them to clinical applications in humans. Hence, more clinical trials based on larger populations need to be carried out to investigate the relevance of stem cell therapy, including its safety and efficacy, in translational infertility medicine.
Keywords: assisted reproduction technology; induced pluripotent stem cell; infertility; mesenchymal stem cell; spermatogonial stem cell.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/8303590/bin/cells-10-01613-g001.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/8303590/bin/cells-10-01613-g002.gif)
![Figure 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/8303590/bin/cells-10-01613-g003.gif)
Similar articles
-
Mesenchymal Stem Cell-based Therapy and Female Infertility: Limitations and Advances.Curr Stem Cell Res Ther. 2023;18(3):322-338. doi: 10.2174/1574888X17666220511142930. Curr Stem Cell Res Ther. 2023. PMID: 35546752
-
Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods.Front Med. 2022 Dec;16(6):827-858. doi: 10.1007/s11684-022-0948-8. Epub 2022 Dec 23. Front Med. 2022. PMID: 36562947 Review.
-
Exploring the future potential of mesenchymal stem/stromal cells and their derivatives to support assisted reproductive technology for female infertility applications.Hum Cell. 2023 Sep;36(5):1604-1619. doi: 10.1007/s13577-023-00941-3. Epub 2023 Jul 5. Hum Cell. 2023. PMID: 37407748 Review.
-
Current Progress in Stem Cell Therapy for Male Infertility.Stem Cell Rev Rep. 2023 Oct;19(7):2073-2093. doi: 10.1007/s12015-023-10577-3. Epub 2023 Jul 13. Stem Cell Rev Rep. 2023. PMID: 37440145 Review.
-
Pregnancy outcomes after assisted human reproduction.J Obstet Gynaecol Can. 2014 Jan;36(1):64-83. doi: 10.1016/S1701-2163(15)30685-X. J Obstet Gynaecol Can. 2014. PMID: 24444289
Cited by
-
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway.Antioxidants (Basel). 2024 Jan 31;13(2):183. doi: 10.3390/antiox13020183. Antioxidants (Basel). 2024. PMID: 38397781 Free PMC article.
-
Current Status and Future Prospects of Stem Cell Therapy for Infertile Patients with Premature Ovarian Insufficiency.Biomolecules. 2024 Feb 19;14(2):242. doi: 10.3390/biom14020242. Biomolecules. 2024. PMID: 38397479 Free PMC article. Review.
-
Stem Cells and Infertility: A Review of Clinical Applications and Legal Frameworks.J Pers Med. 2024 Jan 24;14(2):135. doi: 10.3390/jpm14020135. J Pers Med. 2024. PMID: 38392569 Free PMC article. Review.
-
Fertility Protection, A Novel Concept: Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Protect against Chemotherapy-Induced Testicular Cytotoxicity.Int J Mol Sci. 2023 Dec 20;25(1):60. doi: 10.3390/ijms25010060. Int J Mol Sci. 2023. PMID: 38203232 Free PMC article.
-
Beyond Canine Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Transplantation: An Update on Their Secretome Characterization and Applications.Animals (Basel). 2023 Nov 19;13(22):3571. doi: 10.3390/ani13223571. Animals (Basel). 2023. PMID: 38003188 Free PMC article. Review.
References
-
- Chandra A., Copen C.E., Stephen E.H. Infertility and Impaired Fecundity in the United States, 1982–2010: Data from the National Survey of Family Growth. US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics; Atlanta, GA, USA: 2013. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical