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Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease.
Dedrick RM, Smith BE, Cristinziano M, Freeman KG, Jacobs-Sera D, Belessis Y, Whitney Brown A, Cohen KA, Davidson RM, van Duin D, Gainey A, Garcia CB, Robert George CR, Haidar G, Ip W, Iredell J, Khatami A, Little JS, Malmivaara K, McMullan BJ, Michalik DE, Moscatelli A, Nick JA, Tupayachi Ortiz MG, Polenakovik HM, Robinson PD, Skurnik M, Solomon DA, Soothill J, Spencer H, Wark P, Worth A, Schooley RT, Benson CA, Hatfull GF. Dedrick RM, et al. Among authors: iredell j. Clin Infect Dis. 2023 Jan 6;76(1):103-112. doi: 10.1093/cid/ciac453. Clin Infect Dis. 2023. PMID: 35676823 Free PMC article.
Relatively few active lytic phages are available and there is great variation in phage susceptibilities among M. abscessus isolates, requiring personalized phage identification. ...
Relatively few active lytic phages are available and there is great variation in phage susceptibilities among M. abscessus isolates, …
Refractory Pseudomonas aeruginosa infections treated with phage PASA16: A compassionate use case series.
Onallah H, Hazan R, Nir-Paz R; PASA16 study group; Brownstein MJ, Fackler JR, Horne B, Hopkins R, Basu S, Yerushalmy O, Alkalay-Oren S, Braunstein R, Rimon A, Gelman D, Khalifa L, Adler K, Abdalrhman M, Gelman S, Katvan E, Coppenhagen-Glazer S, Moses A, Oster Y, Dekel M, Ben-Ami R, Khoury A, Kedar DJ, Meijer SE, Ashkenazi I, Bishouty N, Yahav D, Shostak E, Livni G, Paul M, Gross M, Ormianer M, Aslam S, Ritter M, Urish KL, La Hoz RM, Khatami A, Britton PN, Lin RCY, Iredell JR, Petrovic-Fabijan A, Lynch S, Tamma PD, Yamshchikov A, Lesho E, Morales M, Werzen A, Saharia K. Onallah H, et al. Among authors: iredell jr. Med. 2023 Sep 8;4(9):600-611.e4. doi: 10.1016/j.medj.2023.07.002. Epub 2023 Aug 9. Med. 2023. PMID: 37562400
Different IncI1 plasmids from Escherichia coli carry ISEcp1-blaCTX-M-15 associated with different Tn2-derived elements.
Zong Z, Ginn AN, Dobiasova H, Iredell JR, Partridge SR. Zong Z, et al. Among authors: iredell jr. Plasmid. 2015 Jul;80:118-26. doi: 10.1016/j.plasmid.2015.04.007. Epub 2015 Apr 27. Plasmid. 2015. PMID: 25929173
The bla(CTX-M-15) gene, encoding the globally dominant CTX-M-15 extended-spectrum beta-lactamase, has generally been found in a 2.971-kb ISEcp1-bla(CTX-M-15)-orf477delta transposition unit, with ISEcp1 providing a promoter. ...In the novel plasmid pJIE139 (ST …
The bla(CTX-M-15) gene, encoding the globally dominant CTX-M-15 extended-spectrum beta-lactamase, has generally been found in …
CRISPR-Cas System in Antibiotic Resistance Plasmids in Klebsiella pneumoniae.
Kamruzzaman M, Iredell JR. Kamruzzaman M, et al. Among authors: iredell jr. Front Microbiol. 2020 Jan 10;10:2934. doi: 10.3389/fmicb.2019.02934. eCollection 2019. Front Microbiol. 2020. PMID: 31998256 Free PMC article.
All plasmids except two are very large (>200 kb) and half of them carried multiple antibiotic resistance genes including bla (CTX-M) , bla (NDM) , bla (OXA) . To our knowledge, this is the first report of multi drug resistance plasmids from Enterobacteriaceae with their …
All plasmids except two are very large (>200 kb) and half of them carried multiple antibiotic resistance genes including bla (CTX-M …
ISEcp1-mediated transposition and homologous recombination can explain the context of bla(CTX-M-62) linked to qnrB2.
Zong Z, Partridge SR, Iredell JR. Zong Z, et al. Among authors: iredell jr. Antimicrob Agents Chemother. 2010 Jul;54(7):3039-42. doi: 10.1128/AAC.00041-10. Epub 2010 Apr 26. Antimicrob Agents Chemother. 2010. PMID: 20421399 Free PMC article.
bla(CTX-M-62), a C508T variant of bla(CTX-M-3b), was transferred from Klebsiella pneumoniae JIE137 on a conjugative plasmid together with a class 1 integron containing the dfrA12-gcuF-aadA2 cassette array, ISCR1, and qnrB2. bla(CTX-M-62) lies between intact a …
bla(CTX-M-62), a C508T variant of bla(CTX-M-3b), was transferred from Klebsiella pneumoniae JIE137 on a conjugative plasmid to …
Specialised functions of two common plasmid mediated toxin-antitoxin systems, ccdAB and pemIK, in Enterobacteriaceae.
Wu AY, Kamruzzaman M, Iredell JR. Wu AY, et al. Among authors: iredell jr. PLoS One. 2020 Jun 30;15(6):e0230652. doi: 10.1371/journal.pone.0230652. eCollection 2020. PLoS One. 2020. PMID: 32603331 Free PMC article.
Comparisons of ccdAB variants, taken from E. coli and K. pneumoniae, revealed sequence differences, while pemIK variants from IncF and IncL/M plasmids were almost identical. Similarly, the expression and plasmid stability functions of ccdAB variants varied according to the …
Comparisons of ccdAB variants, taken from E. coli and K. pneumoniae, revealed sequence differences, while pemIK variants from IncF and IncL/ …
pEl1573 Carrying blaIMP-4, from Sydney, Australia, is closely related to other IncL/M plasmids.
Partridge SR, Ginn AN, Paulsen IT, Iredell JR. Partridge SR, et al. Among authors: iredell jr. Antimicrob Agents Chemother. 2012 Nov;56(11):6029-32. doi: 10.1128/AAC.01189-12. Epub 2012 Aug 27. Antimicrob Agents Chemother. 2012. PMID: 22926566 Free PMC article.
Complete sequencing of pEl1573, a representative IncL/M plasmid carrying bla(IMP-4) from Sydney, Australia, revealed an 60-kb backbone almost identical to those of IncL/M plasmids pCTX-M3, from Poland, and pCTX-M360, from China, and less closely related to pNDM-HK, …
Complete sequencing of pEl1573, a representative IncL/M plasmid carrying bla(IMP-4) from Sydney, Australia, revealed an 60-kb backbon …
Multidrug-resistant OXA-48/CTX-M-15 Klebsiella pneumoniae cluster in a COVID-19 intensive care unit: salient lessons for infection prevention and control during the COVID-19 pandemic.
Howard-Jones AR, Sandaradura I, Robinson R, Orde SR, Iredell J, Ginn A, van Hal S, Branley J. Howard-Jones AR, et al. Among authors: iredell j. J Hosp Infect. 2022 Aug;126:64-69. doi: 10.1016/j.jhin.2022.05.001. Epub 2022 May 10. J Hosp Infect. 2022. PMID: 35562071 Free PMC article.
FINDINGS: Seven clinical isolates and one environmental carbapenemase-producing Klebsiella pneumoniae isolate - all carrying OXA-48, CTX-M-15 and outer membrane porin mutations in ompK35/ompK36 - were identified with 1 single nucleotide polymorphism difference, indicative …
FINDINGS: Seven clinical isolates and one environmental carbapenemase-producing Klebsiella pneumoniae isolate - all carrying OXA-48, CTX- …
A novel gene cassette, aacA43, in a plasmid-borne class 1 integron.
Partridge SR, Thomas LC, Ginn AN, Wiklendt AM, Kyme P, Iredell JR. Partridge SR, et al. Among authors: iredell jr. Antimicrob Agents Chemother. 2011 Jun;55(6):2979-82. doi: 10.1128/AAC.01582-10. Epub 2011 Mar 21. Antimicrob Agents Chemother. 2011. PMID: 21422220 Free PMC article.
Like related aminoglycoside-(6')-acetyltransferases, AacA43 confers clinically relevant resistance to kanamycin, tobramycin, and some less-used aminoglycosides but not to gentamicin. Although transferable on an IncL/M plasmid, aacA43 was identified in only two different Kl …
Like related aminoglycoside-(6')-acetyltransferases, AacA43 confers clinically relevant resistance to kanamycin, tobramycin, and some less-u …
blaCTX-M-15 carried by IncF-type plasmids is the dominant ESBL gene in Escherichia coli and Klebsiella pneumoniae at a hospital in Ghana.
Agyekum A, Fajardo-Lubián A, Ansong D, Partridge SR, Agbenyega T, Iredell JR. Agyekum A, et al. Among authors: iredell jr. Diagn Microbiol Infect Dis. 2016 Apr;84(4):328-33. doi: 10.1016/j.diagmicrobio.2015.12.010. Epub 2015 Dec 17. Diagn Microbiol Infect Dis. 2016. PMID: 26830052
Investigation of the resistance phenotypes of 101 consecutive clinical E. coli (n=58) and K. pneumoniae (n=43) isolated at the Komfo Anokye Teaching Hospital in Ghana over 3 months revealed 63 (62%) with an ESBL phenotype. All 63 had a blaCTX-M gene, and sequence analysis …
Investigation of the resistance phenotypes of 101 consecutive clinical E. coli (n=58) and K. pneumoniae (n=43) isolated at the Komfo Anokye …
20 results