Vice President Program Management - Team Lead

Actinium Pharmaceuticals, Inc. is a late-stage biopharmaceutical company developing targeted radiotherapies intended to meaningfully improve survival for patients with relapsed or refractory cancer who have failed existing therapies. Our vision is to build a specialty, hospital-focused, radiotherapeutics company that develops and markets medicines for patients who are treated primarily in large quaternary care hospitals and their catchment areas. We are deploying our technology platform, which we believe to be industry-leading, to develop ARCs, or Antibody Radiation Conjugates, and next-generation radiotherapies against validated cancer targets.

Our Iomab-B and Actimab-A advanced ARC product candidates fill the major unmet medical needs in relapsed or refractory AML in a complementary fashion directed at different parts of the patient journey. Iomab-B is being developed as a targeted bridging therapy candidate that we believe could provide both disease control and conditioning in one agent. Actimab-A is a targeted therapy that has demonstrated the potential to extend survival outcomes for people with r/r AML and is poised for advanced development in collaboration with the National Cancer Institute. Together, we believe these two product candidates could provide us the opportunity to transform the treatment of AML, especially in the relapsed and refractory segment which represents over 50% of AML patients. Based on early clinical trial results, we are also developing our Iomab-ACT program – a next generation conditioning program for rapidly growing cell and gene therapies.

Our R&D capabilities have the potential to yield differentiated, high-value ARC programs that demonstrate our experience across multiple validated cancer targets and isotopes and cover broad areas of focus leveraging our clinical development experience across hematology, targeted conditioning, solid tumors, and next generation ARCs. Our intellectual property portfolio includes more than 230 patents and patent applications worldwide. The position will provide program management and leadership for all phases of development, from pre-IND through late-stage clinical development for our pipeline.

This position will work with Department Leads to ensure that clear strategic plans are developed and managed, along with the associated resources and budgets, in order to execute those plans. The VP, Program Management will have the ability to lead and work with complex multi-functional project teams. In addition, this role will require exceptional knowledge of steps involved in innovative R&D and drug development, will be able to identify interdependencies and issues early on, and will work with key stakeholders to solve problems and ensure project deliverables are completed within stipulated timelines.

Key Responsibilities:

• Lead and drive early phase development and implementation of comprehensive solid tumor program strategy to ensure successful program positioning for subsequent late-stage development and registrational studies
• In partnership with the, matrix team, define the strategic development objectives for assigned projects and establish accurate strategic plan (activities, timelines, and budget) that clearly outline the project scope and vision
• Identify, coordinate, and monitor activities, tasks and resources that are required by different functions and external organizations for each project
• Set and manage clear and measurable objectives for each project
• Manage governance process and drive execution by teams, with attention to clear goals, plans and evaluation of opportunities and risks
• Ensure alignment of the program goals and strategy with clearly defined decision points throughout the program
• Build and maintain project schedules and plan and sequence activities, including milestones, decision points and scenario development
• Identified key program performance measures and tracked against integrated development plan that defined the critical path, risk activities, and inter-dependencies
• Ensure seamless execution, including clear program tracking and progress reporting
• Provide hands-on planning and manage day-to-day operations of the Project Team, including dissemination of information, as appropriate
• Ensure cross-functional alignment and integration across functional teams
• Responsible for the overall quality, accuracy, and maintenance of the integrated program plan, budget, and documentation
• Responsible for timely development of project meeting agendas and clear and accurate meeting minutes, including action items
• Proactively manage scope and timelines to ensure project deliverables are being met on-time, continuously monitoring and identifying activities on the critical path and, when appropriate, coordinating efforts to optimize development pl
• correct deviations from plans or budgets
• Liaise with Finance to develop, track, and report on program budgets and costs
• Identify novel ideas and opportunities for business process improvements, recommend solutions, and provide input to leadership regarding priorities and resource allocation to meet goals
• Prospectively identify/evaluate project risks and coordinate risk minimization strategies and contingency planning
• Identify and help resolve program issues
• Provide timely communication to senior management (monthly updates, meeting minutes, key program milestones and program deliverables, etc.) to ensure alignment
• Support development of project management, including sharing of learnings and best practices across matrixed project teams

Qualifications:

• Bachelor’s Degree, graduate degree preferred (MBA, MS, PhD)
• Minimum 15 years in the biopharmaceutical industry with at least 10 years in program management
• Experience in program management in biotech and/or pharma, in particular, with biologics, ADCs, and/or radiotherapeutics
• Experience working in both large and smaller companies, including a matrixed organization
• Strong analysis and problem-solving skills
• Executive presence, with strong verbal and written communication skills across multiple levels of an organization, including senior leadership
• Excellent organizational skills and an ability to prioritize effectively to deliver results within timelines
• Strong interpersonal skills, including verbal and written communication
• Must be a self-starter and have the ability to influence and lead a project through the various stages of drug development
• Must be able to build relationships with the functional team members in order to ensure complete understanding of the overall project strategy and ensure operational excellence
• Experience leading cross-functional project teams responsible for work in preclinical development through late-stage development, including requirements to successfully obtain product approval
• Proven track record of delivering on-time, on-budget, and achieving results
• High skill level in Project Management using MS Project, PowerPoint, Excel, and SharePoint

Compensation will be commensurate with experience. Actinium offers competitive base salaries, performance bonuses, equity incentive plans, 401(K) with company matching and comprehensive health benefits.