Brooke M. Emerling, Ph.D., is contributing to a revival of interest in an underappreciated set of enzymes called phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks). Emerling and team have now shown for the first time that PI5P4K activity is connected to the regulation of an ancient signaling system called the hippo pathway, which is found in a wide variety of organisms and is known to help human organs grow and control their size. In a study published in Science Signaling, Emerling and co-senior author Raymond Blind, Ph.D., at Vanderbilt University Medical Center, shared their findings, which open new research avenues to tackle aggressive cancers. Read more: https://bit.ly/3Vhg3wh #enzymes #PI5P4K #cancerresearch
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๐๐ฑ Exploring the Building Blocks of Life: Unraveling the Role of Cytokines and Growth Factors with EC BIOLABS ๐๐ฑ Calling all life science explorers! Delve into the intricate world of cytokines and growth factors with EC Biolabs and uncover the fundamental principles that govern cellular behavior and tissue development. These multifaceted molecules serve as the cornerstone of biological regulation, influencing processes ranging from inflammation and wound healing to embryogenesis and organogenesis. With our comprehensive range of cytokines and growth factors, you can dissect the molecular mechanisms underlying health and disease, paving the way for novel therapeutic interventions and clinical advancements. Ready to embark on a journey of scientific discovery? Contact us at info@ecbiolabs.com to learn more about our premium cytokines and growth factors and revolutionize your research today! ๐๐ฌ #ECBiolabs #Cytokines #GrowthFactors #LifeSciences #Innovation
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Congratulations to Drs. Simon Abrams, Guozheng Wang, and the research teams at the University of Liverpool and the University of Glasgow for their outstanding achievement in having their research published as the Cover Article in the Journal of Thrombosis and Haemostasis. The study focuses on the role of damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia (VITT). Akoya's PhenoImager platform and Opal-TSA multi-plex chemistry were used to image the patient's kidney and liver tissues. Their findings suggest that coupling systemic cell damage and death with strong immune-inflammatory and coagulant responses is pathophysiologically dominant and clinically relevant in severe VITT. Read the paper: https://bit.ly/3TIajJV #AkoyaInAction #SpatialBiology #PhenoImager
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Excited to announce our recent publication in the International Journal of Biological Macromolecules, which boasts an impressive impact factor of 8.025! Our researcher Dr. Mitesh Patel, Assistant Professor at Parul University, delves into the innovative inhibition of microtubule affinity regulating kinase 4 (MARK4) by Harmaline as a potential strategy to combat Alzheimerโs disease. Authors : Mohd Adnan, Saleha Anwar, Debarati DasGupta, Mitesh Patel, Abdelbaset Mohamed Elasbali, Hassan H. Alhassan, Alaa Shafie, Arif Jamal Siddiqui, Fevzi Bardakci, Mejdi Snoussi, Md. Imtaiyaz Hassan Key Highlights of Our Research: 1. Identified that the hyperphosphorylation of tau protein by MARK4 plays a crucial role in Alzheimerโs disease pathogenesis. 2. Findings suggest that inhibiting MARK4 with Harmaline could be a promising approach for managing Alzheimer's. 3. Docking and molecular dynamics (MD) simulations demonstrated the formation of a stable complex between MARK4 and Harmaline, indicating a strong interaction. 4. Further validation through fluorescence and isothermal titration calorimetry (ITC) revealed a strong binding affinity of Harmaline for MARK4. 5. Harmaline was shown to inhibit the kinase activity of MARK4, effectively controlling the hyperphosphorylation of tau protein. This groundbreaking research opens new avenues for developing treatments targeting critical factors in Alzheimerโs disease progression. We are eager to explore the potential implications of these findings and continue our efforts in this vital area of study. Read the full paper here: https://lnkd.in/dXFMBzT4 #AlzheimersResearch #BiologicalMacromolecules #ParulUniversity #ScientificResearch #AcademicExcellence #AlzheimersDisease #HealthcareInnovation #NeurodegenerativeDiseases #ResearchAndDevelopment #Scope #ParulUniversity
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Targeting Mitochondria 2023 Poster Presentation award! Tatjana Kuen from the Leopold-Franzens Universitรคt Innsbruck (Austria) was discerned the best post award for her poster titled "Inhibitors of Fumarylacetoacetate Domain Containing Protein 1 (FAHD1) Induce Premature Cellular Senescence in Human Endothelial Fibroblasts in Vitro". The abstract of the award winning poster is included in the Targeting Mitochondria 2023 abstracts book. #WorldMitochondriaSociety #TargetingMitochondria2023 #mitochondria
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Seminar Recap: Mitochondrial Targeted Regulation and Disease Therapy ๐งฌ Had an insightful session at SJTU-BME School of Biomedical Engineering on Oct 31, 2023. Prof. Jiang Hulin discussed the potential of mitochondrial targeting nanoparticles for diseases. ๐ Key Points: Mitochondria's role in energy metabolism and apoptosis. Strategies for treating tumors, fibrosis, and rare diseases via mitochondrial DNA regulation. About Prof. Jiang Hulin: ๐ Professor of Xingyao, PhD Supervisor ๐ Distinguished Professor of Jiangsu Province ๐ Visiting Professor of Sungkyunkwan University Kudos to Dr. Wang Feihu for organizing this enlightening talk! #stemcells #biomaterials #immunotherapy #cellengineering #regenerationmedicine #BiomedicalEngineering #MitochondrialTherapy #ResearchTalk #ScienceSeminar #ShanghaiJiaotongUniversity
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๐ An interesting read Universitรคt Rostock researchers published a paper documenting the impact of oxidative stress on mesenchymal stem/stromal cells (MSCs) using the IDEA Bio-Medical Hermes system. โก They reported that reactive oxygen species (ROS) levels are linked to immune cell activation, which can affect various cells and that oxidative stress might hinder the regenerative abilities of MSC's. ๐ฌ The #Hermes system was used to study the short & long-term oxidative stress effects on MSC, gaining unprecedented insights into NF-ากB translocation measurements, cell migration assays, and cell counts. โกResults show that MSC viability, migration, differentiation, and signalling were all influenced by oxidative stress, underlining its broad impact. This report highlights the critical effect of oxidative stress and MSC functions, with potential implications for regenerative medicine.
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Our most popular story of 2023 involves an international team of researchers, including Nicholas Banovich, Ph.D., who detail the largest and most comprehensive map of cells in the human lung in a study published in Nature Medicine. The Human Lung Cell Atlas provides valuable insights into lung diseases and highlights the differences between healthy and diseased lungs. By combining data from nearly 40 studies, the team created the first integrated single-cell atlas of the lung. This atlas, which includes over 2.4 million cells from 486 individuals, offers new understanding of lung biology and the potential for identifying new therapeutic targets. https://bit.ly/49QRgnY
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New video: Dr. Abdullah Khan, senior research fellow at the MRC WIMM, University of Oxford, is pioneering next-generation human models to study health and disease, with a focus on the bone marrow. In this video, Dr. Khan discusses the challenges of working with organoids, the key technologies he employs, and his aspirations for translating treatments into precision and personalized medicine in the future. โก๏ธ Watch it here: https://lnkd.in/gZ7yvtxJ #bonemarrow #disease #personalizedmedicine MRC Weatherall Institute of Molecular Medicine
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Last 3 weeks of research on #mitochondrialdisease! https://lnkd.in/duAwZNkz https://lnkd.in/dyZDbAZp https://lnkd.in/dVPm7QfM Biomed News Gavin McStay Keshav K Singh, PhD World Mitochondria Society The Mitochondria Research and Medicine Society The Society for Mitochondrial Research and Medicine MitoWomen Network Highlight The rate and nature of mitochondrial DNA mutations in human pedigrees Arnadottir et al
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๐ ๐ถ๐๐ผ๐ฐ๐ต๐ผ๐ป๐ฑ๐ฟ๐ถ๐ฎ ๐ฎ๐ ๐๐ต๐ฒ ๐ก๐ฒ๐ ๐๐ ๐ผ๐ณ ๐ ๐ฒ๐๐ฎ๐ฏ๐ผ๐น๐ถ๐๐บ, ๐๐ด๐ถ๐ป๐ด, ๐ฎ๐ป๐ฑ ๐๐ถ๐๐ฒ๐ฎ๐๐ฒ โญ Thus, this new line of research has been published in the medical journal: ๐๐ณ๐ฐ๐ฏ๐ต๐ช๐ฆ๐ณ๐ด ๐ช๐ฏ ๐๐ฆ๐ญ๐ญ ๐ข๐ฏ๐ฅ ๐๐ฆ๐ท๐ฆ๐ญ๐ฐ๐๐ฎ๐ฆ๐ฏ๐ต๐ข๐ญ ๐๐ช๐ฐ๐ญ๐ฐ๐จ๐บ, with surprising advances in the cellular biology of the mitochondria, involved in well-known functions such as cellular respiration, but now understanding its role in pathologies such as: โ Ageing โ Neurodegeneration โ Metabolic disease โ Cancer Many years of research have passed since we understood the primary role of mitochondria in the Krebs cycle ๐ฅ for cellular oxygenation to such complex processes, demonstrating how mitochondria contribute to the regulation of nutrient-sensing and signaling pathways. These pathways, for example, when activated, ๐ฝ๐ฟ๐ผ๐บ๐ผ๐๐ฒ ๐น๐ถ๐ณ๐ฒ๐๐ฝ๐ฎ๐ป in flies, worms and in mice through controlled diet compositions and timing of food intake. ๐ฏ ๐ A great series of scientific articles published about the ๐ข๐๐ฉ๐ค๐๐๐ค๐ฃ๐๐ง๐๐, an organelle that only has a diameter of ๐ญ - ๐ฎ ฮผ๐บ and a length of approximately ๐ด ฮผ๐บ in the new edition of ๐๐ณ๐ฐ๐ฏ๐ต๐ช๐ฆ๐ณ๐ด ๐ช๐ฏ ๐๐ฆ๐ญ๐ญ ๐ข๐ฏ๐ฅ ๐๐ฆ๐ท๐ฆ๐ญ๐ฐ๐๐ฎ๐ฆ๐ฏ๐ต๐ข๐ญ ๐๐ช๐ฐ๐ญ๐ฐ๐จ๐บ Series of articles โถ๏ธ https://lnkd.in/evDnfhyx
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Board Certified Regulatory Toxicologist Assuring Safety for Food, Feed, and Nutrition Products
1moCongratulations to you and your team Brooke M. Emerling ! Nice work.