In a recently accepted Cell Reports paper, Cristiana Dondi, PhD (a postdoc in Dr. Karen Ocorr's lab) suggested that CRTC signaling, previously characterized for its role in the liver and in neurons, plays a conserved and cardiac-autonomous role in maintaining heart structure and function, in part by regulating Sarcalumenin expression which in turn modulates cytosolic Ca2+ levels. Her data in Drosophila show that CRTC null mutants exhibit reduced fat stores, severe cardiac restriction, myofibrillar disorganization, cardiac fibrosis, and tachycardia, all hallmarks of heart disease, while cardiac-overexpression (OE) of CRTC caused hypertrophy with upregulation of specific hypertrophy markers. They also identified the fly ortholog of Sarcalumenin (Srl), a Ca2+-binding protein of the sarcoplasmic reticulum, as a likely downstream target. Additional data from zebrafish and hIPSC-CMs show that CRTC - SRL signaling likely represents a new and conserved pathway mediating cardiac hypertrophy. Dr. Dondi shared her findings this week with the Sanford Burnham Prebys research community as part of the SBP Seminar Series. https://lnkd.in/gezPu2Bg
Office of Education, Training, & International Services
Education Administration Programs
La Jolla, California 937 followers
We support Sanford Burnham Prebys trainees by providing educational & professional dev. programs and DEI initiatives.
About us
We highlight accomplishments in the Sanford Burnham Prebys education and training community, share career tips/resources/articles, and welcome discussions about biomedical Ph.D. education and postdoctoral training.
- Website
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http://www.sbpdiscovery.org/education
External link for Office of Education, Training, & International Services
- Industry
- Education Administration Programs
- Company size
- 501-1,000 employees
- Headquarters
- La Jolla, California
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- 1976
Updates
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Join our team and have an impact on biomedical education and training! We are looking for a Program Manager for the Sanford Burnham Prebys Graduate School of Biomedical Sciences who will focus on Recruitment and Pathway Programs. For more information and to apply: https://lnkd.in/gT2cR34D
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Postdocs and early-career PhDs: Are you looking to enhance your leadership skills? Apply now to participate in our comprehensive leadership development program: Foundations of Leadership. In this program, participants will explore the inherent and environmental aspects of their behaviors to gain a holistic understanding of their priorities, preferences, and motivations. The program provides frameworks, tools, and case scenario discussions towards helping you develop your leadership, conflict management, communication, influence, and negotiation skills. Applications are due July 8, 2024! Learn more about this program and how to apply at: https://lnkd.in/gc5vWGYD.
Foundations of Leadership: Core Concepts for Building Your Leadership Style
sbpleaders.org
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Another great moment for our graduate students, postdocs and Staff Scientists! This month’s Breakfast Club, hosted by the Sanford Burnham Prebys Science Network (SBP-SN), featured Assistant Professor Dr. Caroline Kumsta who was very generous in sharing her mentoring philosophy, her career’s successes and challenges as well as her personal experiences. SBP-SN is very excited to see how this initiative keeps growing and looks forward to having more graduate students and postdocs join us at the next Breakfast Club!
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Celebrating Doctor Zong Ming Chua, who successfully defended his #phd dissertation at Sanford Burnham Prebys on Wed., 6/12! 👨🎓 #phdstudent #doctorate #success #congratulations
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So happy to welcome back two of our California Institute for Regenerative Medicine (CIRM)-SPARK alumni today as well as our first Diversity in Science Seminar Series speaker of the Summer, Dr. Dina Greene!
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Celebrating #diversity @ Sanford Burnham Prebys: Our California Institute for Regenerative Medicine (CIRM)-funded #SPARK interns officially started (seen below touring our animal facility!) followed by the annual raising of our #pride flag this afternoon. 🏳️🌈 #dei #deib #equity #stem
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Congratulations to Sanford Burnham Prebys postdoc Chiara Nicoletti, Ph.D. (Dr. Lorenzo Puri’s lab) for winning a Young Investigator Award from the Jain Foundation Inc.! In Chiara’s own words: “ I am honored by the trust they show me with this award, considering it’s a Foundation of patients and their families. I hope to be able to contribute to finding a cure for dysferlinopathy, a pressing need for the people whose lives are deeply impacted by this disease.” https://lnkd.in/g5yKNdix
We congratulate the winners of the Young Investigators Awards from the 2024 Dysferlin Conference. Alastair Khodabukus, Ph.D.,laboratory of Prof. Nenad Bursac, Duke University—Ali was instrumental in developing techniques for growing functional myobundles from iPS cells, and for characterizing and investigating several phenotypic abnormalities in dysferlin-deficient myobundles, involving calcium handling, cholesterol homeostasis, and metabolism. His work has yielded new insights into the function of dysferlin and identified potential treatment approaches. Stacey Nicole Keenan, Ph.D., laboratory of Prof. Matthew Watt, University of Melbourne—Stacey’s work has led to the identification and characterization of the extensive changes in lipid composition, storage, metabolism, and regulation that occur in muscle as a result of dysferlin deficiency. This work has shown the lipid abnormalities to be a distinctive key feature of dysferlinopathy, rather than a nonspecific downstream effect, raising potential therapeutic targets. Chiara Nicoletti, Ph.D., laboratory of Prof. Lorenzo Puri, Sanford Burnham Prebys Medical Discovery Institute—Chiara has played a leading role in data analysis in an ambitious undertaking involving three research groups to characterize single cell- and single nucleus gene expression in dysferlin deficient muscle. It has been known that in dysferlin deficiency there are large numbers of inflammatory infiltrates, but characterizing the cells, what genes they are expressing, and how they interact with each other is challenging. Chiara’s work in analyzing this large data set has been instrumental in increasing our understanding.
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Last Friday afternoon, 4 of our #graduates from Sanford Burnham Prebys returned to campus for our inaugural graduation and hooding ceremony. So proud of all of them!🎓🧑🎓👩🎓 #phd #biomedicalresearch #graduateschool
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The SBP Science Network (SBP-SN) recently launched an exciting new initiative called the Breakfast Club Series, aimed at bringing Sanford Burnham Prebys postdocs and graduate students and PIs together in a casual environment to connect and engage in discussions regarding academic journeys. On Wednesday May 29th, some of our postdocs, graduate students and staff scientists met with Dr. Kelly Kersten, a new Faculty member, gaining insights into her scientific journey, experiences, and the intricacies of being a PI—the perks they enjoy and the challenges they face. It was an unique chance for an enriching discussion over a delightful breakfast spread!
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