Fgf and Bmp signals repress the expression of Bapx1 in the mandibular mesenchyme and control the position of the developing jaw joint
- PMID: 14729484
- DOI: 10.1016/j.ydbio.2003.10.012
Fgf and Bmp signals repress the expression of Bapx1 in the mandibular mesenchyme and control the position of the developing jaw joint
Abstract
The development of the jaw joint between the palatoquadrate and proximal part Meckel's cartilage (articular) has recently been shown to involve the gene Bapx1. Bapx1 is expressed in the developing mandibular arch in two distinct caudal, proximal patches, one on either side of the head. These domains coincide later with the position of the developing jaw joint. The mechanisms that result in the restricted expression of Bapx1 in the mandibular arch were investigated, and two signaling factors that act as repressors were identified. Fibroblast growth factors (Fgfs) expressed in the oral epithelium restrict expression of Bapx1 to the caudal half of the mandibular arch, while bone morphogenetic proteins (Bmps) expressed in the distal mandibular arch restrict expression of Bapx1 to the proximal part of the mandible. Application of Fgf8 and Bmp4 beads to the proximal mesenchyme led to loss of Bapx1 expression and later fusion of the quadrate and articular as the jaw joint failed to form. In addition to fusion of the jaw joint, loss of Bapx1 lead to loss of the retroarticular process (RAP), phenocopying the defects seen after Bapx1 function was reduced in the zebrafish. By manipulating these signals, we were able to alter the expression domain of Bapx1, resulting in a new position of the jaw joint.
Similar articles
-
Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution.Development. 2004 Mar;131(6):1235-45. doi: 10.1242/dev.01017. Epub 2004 Feb 18. Development. 2004. PMID: 14973294
-
Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint.Development. 2003 Apr;130(7):1353-65. doi: 10.1242/dev.00339. Development. 2003. PMID: 12588851
-
Region- and stage-specific effects of FGFs and BMPs in chick mandibular morphogenesis.Dev Dyn. 2002 Mar;223(3):333-52. doi: 10.1002/dvdy.10056. Dev Dyn. 2002. PMID: 11891984
-
Morphogenesis of the medial region of the developing mandible is regulated by multiple signaling pathways.Cells Tissues Organs. 2001;169(3):295-301. doi: 10.1159/000047894. Cells Tissues Organs. 2001. PMID: 11455126 Review.
-
BMP/GDF-signalling interactions during synovial joint development.Cell Tissue Res. 1999 Apr;296(1):111-9. doi: 10.1007/s004410051272. Cell Tissue Res. 1999. PMID: 10199971 Review.
Cited by
-
PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation.Development. 2022 Feb 15;149(4):dev200082. doi: 10.1242/dev.200082. Epub 2022 Feb 24. Development. 2022. PMID: 35132438 Free PMC article.
-
The broad role of Nkx3.2 in the development of the zebrafish axial skeleton.PLoS One. 2021 Aug 19;16(8):e0255953. doi: 10.1371/journal.pone.0255953. eCollection 2021. PLoS One. 2021. PMID: 34411150 Free PMC article.
-
Conserved and unique transcriptional features of pharyngeal arches in the skate (Leucoraja erinacea) and evolution of the jaw.Mol Biol Evol. 2021 Sep 27;38(10):4187-4204. doi: 10.1093/molbev/msab123. Mol Biol Evol. 2021. PMID: 33905525 Free PMC article.
-
Zebrafish model for spondylo-megaepiphyseal-metaphyseal dysplasia reveals post-embryonic roles of Nkx3.2 in the skeleton.Development. 2021 Jan 25;148(2):dev193409. doi: 10.1242/dev.193409. Development. 2021. PMID: 33462117 Free PMC article.
-
The power of zebrafish models for understanding the co-occurrence of craniofacial and limb disorders.Genesis. 2021 Feb;59(1-2):e23407. doi: 10.1002/dvg.23407. Epub 2021 Jan 4. Genesis. 2021. PMID: 33393730 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
