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. 2008 Jun;19(6):2503-13.
doi: 10.1007/s10856-008-3389-2. Epub 2008 Feb 12.

Development of two alginate-based wound dressings

Chih-Tung Chiu  1 , Jui-Sheng Lee, Chi-Shung Chu, Yi-Pin Chang, Yng-Jiin Wang
Affiliations

Development of two alginate-based wound dressings

Chih-Tung Chiu et al. J Mater Sci Mater Med. 2008 Jun.

Abstract

Two types of new alginate-based wound dressings, Type-AP and Type-AE, were fabricated by the EDC-activated crosslinking of alginate with Polyethyleneimine and Ethylenediamine, respectively. As compared with the commercial non-woven wound dressing, Kaltostat, both Type-AP and Type-AE dressings had higher degradation temperature, lower calcium content, and a sponge-like macroporous structure. In addition, these two alginate-based dressings had higher mechanical stress (12.37 +/- 1.72 and 6.87 +/- 0.5 MPa for Type-AP and -AE, respectively) and higher water vapor transmission rates (both about 3,500 g/m2/day) than Kaltostat (0.87 +/- 0.12 MPa and 2,538 g/m2/day). Fibroblasts proliferated faster on these two newly developed wound dressings at a higher rate as compared with that on Kalostat dressing. The results of animal study showed that the wounds treated with either Type-AP or Type-AE dressings healed faster than Kaltostat with less encapsulation of residuals by fibrous tissue and more neo-capillary formation. These two newly developed Type-AP and Type-AE porous wound dressings thus have great potential for clinical applications.

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