Human genetics shape the gut microbiome
- PMID: 25417156
- PMCID: PMC4255478
- DOI: 10.1016/j.cell.2014.09.053
Human genetics shape the gut microbiome
Abstract
Host genetics and the gut microbiome can both influence metabolic phenotypes. However, whether host genetic variation shapes the gut microbiome and interacts with it to affect host phenotype is unclear. Here, we compared microbiotas across >1,000 fecal samples obtained from the TwinsUK population, including 416 twin pairs. We identified many microbial taxa whose abundances were influenced by host genetics. The most heritable taxon, the family Christensenellaceae, formed a co-occurrence network with other heritable Bacteria and with methanogenic Archaea. Furthermore, Christensenellaceae and its partners were enriched in individuals with low body mass index (BMI). An obese-associated microbiome was amended with Christensenella minuta, a cultured member of the Christensenellaceae, and transplanted to germ-free mice. C. minuta amendment reduced weight gain and altered the microbiome of recipient mice. Our findings indicate that host genetics influence the composition of the human gut microbiome and can do so in ways that impact host metabolism.
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Comment in
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Metagenomics: Shaping the gut microbiome.Nat Rev Genet. 2015 Jan;16(1):2. doi: 10.1038/nrg3869. Epub 2014 Nov 18. Nat Rev Genet. 2015. PMID: 25404113 No abstract available.
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References
-
- Bloemen JG, Venema K, van de Poll MC, Olde Damink SW, Buurman WA, Dejong CH. Short chain fatty acids exchange across the gut and liver in humans measured at surgery. Clin Nutr. 2009;28:657–661. - PubMed
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