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Review
. 2015 Aug 5;9(1):278.
doi: 10.4081/oncol.2015.278. eCollection 2015 Feb 10.

Simulants of Malignant Melanoma

Gérald E Piérard  1 , Claudine Piérard-Franchimont  2 , Philippe Delvenne  3
Affiliations
Review

Simulants of Malignant Melanoma

Gérald E Piérard et al. Oncol Rev. .

Abstract

During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further suggested such as MELTUMP (after melanocytic tumor of uncertain malignant potential) and STUMP (after Spitzoid melanocytic tumor of uncertain malignant potential). In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM) variants, are grouped under the tentative broad heading skin melanocytoma. Such set of AMN frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas), and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and MM remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any malignancy risk if present.

Keywords: Melanoma; Spitzoid tumor; cell proliferation; immunohistochemistry; melanocytoma; prognostic factor; risk stratification.

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Conflict of interest statement

Conflict of interest: the authors declare no conflict of interest.

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References

    1. Uhoda I, Quatresooz P, Fumal I, et al. Updating trends in cutaneous cancers in south-east Belgium. Oncol Rep 2004;12:111-4. - PubMed
    1. Smoller BR. Histologic criteria for diagnosing primary cutaneous malignant melanoma. Mod Pathol 2006;19:S34-40. - PubMed
    1. Grant-Kels JM, Bason ET, Grin CM. The misdiagnosis of malignant melanoma. J Am Acad Dermatol 1999;40:539-48. - PubMed
    1. Brochez L, Verhaeghe E, Grosshans E, et al. Inter-observer variation in the histopathological diagnosis of clinically suspicious pigmented skin lesions. J Pathol 2002;196:459-66. - PubMed
    1. Cook MG. Diagnostic pitfalls with melanocytic tumours. Curr Diag Pathol 2004;10:463-72.