Nitroglycerin
- PMID: 29494004
- Bookshelf ID: NBK482382
Nitroglycerin
Excerpt
Nitroglycerin is a vasodilatory drug used primarily to provide relief from anginal chest pain. It is currently FDA approved for the acute relief of an attack or acute prophylaxis of angina pectoris secondary to coronary artery disease. Off-label, non-FDA-approved uses include treatment for hypertensive urgency/emergency, coronary artery spasm, angina secondary to cocaine use, congestive heart failure (CHF), and chronic anal fissures. This activity outlines the indications, mechanism of action, methods of administration, important adverse effects, contraindications, monitoring, and toxicity of nitroglycerin, so providers can direct patient therapy successfully in instances where nitroglycerin benefits patient care.
Copyright © 2024, StatPearls Publishing LLC.
Conflict of interest statement
Sections
Similar articles
-
Nifedipine.2023 May 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 May 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30725737 Free Books & Documents.
-
Selective Beta-1 Blockers.2023 Jan 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jan 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29763157 Free Books & Documents.
-
Enhanced External Counterpulsation (EECP): An Evidence-Based Analysis.Ont Health Technol Assess Ser. 2006;6(5):1-70. Epub 2006 Mar 1. Ont Health Technol Assess Ser. 2006. PMID: 23074496 Free PMC article.
-
Nitroglycerin Use in the Emergency Department: Current Perspectives.Open Access Emerg Med. 2022 Jul 9;14:327-333. doi: 10.2147/OAEM.S340513. eCollection 2022. Open Access Emerg Med. 2022. PMID: 35847764 Free PMC article. Review.
-
Nitrate therapy for angina pectoris. Current concepts about mechanism of action and evaluation of currently available preparations.Arch Intern Med. 1985 Mar;145(3):538-43. doi: 10.1001/archinte.145.3.538. Arch Intern Med. 1985. PMID: 3919668 Review.
References
-
- Parratt JR. Nitroglycerin--the first one hundred years: new facts about an old drug. J Pharm Pharmacol. 1979 Dec;31(12):801-9. - PubMed
-
- Thadani U, Lipicky RJ. Short and long-acting oral nitrates for stable angina pectoris. Cardiovasc Drugs Ther. 1994 Aug;8(4):611-23. - PubMed
-
- Brown BG, Bolson E, Petersen RB, Pierce CD, Dodge HT. The mechanisms of nitroglycerin action: stenosis vasodilatation as a major component of the drug response. Circulation. 1981 Dec;64(6):1089-97. - PubMed
-
- Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP. Molecular mechanism of cGMP-mediated smooth muscle relaxation. J Cell Physiol. 2000 Sep;184(3):409-20. - PubMed
Publication types
LinkOut - more resources
Full Text Sources