Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Oct 8;5(3):MMT11.
doi: 10.2217/mmt-2018-0003. eCollection 2018 Sep.

Combatting mucosal melanoma: recent advances and future perspectives

Helen Tyrrell  1 , Miranda Payne  1
Affiliations
Review

Combatting mucosal melanoma: recent advances and future perspectives

Helen Tyrrell et al. Melanoma Manag. .

Abstract

Mucosal melanomas are a rare subtype of melanoma and are associated with a particularly poor prognosis. Due to the rarity of the diagnosis, and the pace with which the management of cutaneous melanoma has evolved over recent years, there is little good evidence to guide management and evidence-based clinical guidelines are still in development in the UK. In this review we provide an overview of the management of mucosal melanoma, highlighting the critical differences between cutaneous and mucosal melanomas, before examining recent advances in the systemic treatment of this disease and likely future directions.

Keywords: imatinib; ipilimumab; mucosal melanoma; nivolumab; pembrolizumab.

PubMed Disclaimer

Conflict of interest statement

Financial & competing interests disclosure M Payne discloses funding for attendance at conferences, speakers’ fees, and honoraria for participation in advisory boards from GSK, BMS, Novartis, Incyte, and MSD. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. UK CRUK. Skin cancer incidence statistics. www.cancerresearchuk.org/health-professional/cancer-statistics
    1. Mihajlovic M, Vlajkovic S, Jovanovic P, Stefanovic V. Primary mucosal melanomas: a comprehensive review. Int. J. Clin. Exp. Pathol. 2012;5(8):739–753. - PMC - PubMed
    1. Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998;83(8):1664–1678. - PubMed
    1. Furney SJ, Turajlic S, Stamp G, et al. Genome sequencing of mucosal melanomas reveals that they are driven by distinct mechanisms from cutaneous melanoma. J. Pathol. 2013;230(3):261–269. - PubMed
    1. Lian B, Cui CL, Zhou L, et al. The natural history and patterns of metastases from mucosal melanoma: an analysis of 706 prospectively-followed patients. Ann. Oncol. 2017;28(4):868–873. - PubMed

LinkOut - more resources