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Review
. 2019 Jul;35(7):501-515.
doi: 10.1016/j.pt.2019.04.009. Epub 2019 May 29.

Helminth Therapy - From the Parasite Perspective

Kateřina Sobotková  1 , William Parker  2 , Jana Levá  3 , Jiřina Růžková  1 , Julius Lukeš  3 , Kateřina Jirků Pomajbíková  4
Affiliations
Review

Helminth Therapy - From the Parasite Perspective

Kateřina Sobotková et al. Trends Parasitol. 2019 Jul.

Abstract

Studies in animal models and humans suggest that intentional exposure to helminths or helminth-derived products may hold promise for treating chronic inflammatory-associated diseases (CIADs). Although the mechanisms underlying 'helminth therapy' are being evaluated, little attention has been paid to the actual organisms in use. Here we examine the notion that, because of the complexity of biological symbiosis, intact helminths rather than helminth-derived products are likely to prove more useful for clinical purposes. Further, weighing potential cost/benefit ratios of various helminths along with other factors, such as feasibility of production, we argue that the four helminths currently in use for CIAD treatments in humans were selected more by happenstance than by design, and that other candidates not yet tested may prove superior.

Keywords: Biome Depletion Theory; Hymenolepis diminuta; Necator americanus; Old Friends Hypothesis; Trichuris suis ova; helminth therapy.

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