Idi na sadržaj

BNC2

S Wikipedije, slobodne enciklopedije
BNC2
Identifikatori
AliasiBNC2
Vanjski ID-jeviOMIM: 608669 MGI: 2443805 HomoloGene: 18243 GeneCards: BNC2
Lokacija gena (čovjek)
Hromosom 9 (čovjek)
Hrom.Hromosom 9 (čovjek)[1]
Hromosom 9 (čovjek)
Genomska lokacija za BNC2
Genomska lokacija za BNC2
Bend9p22.3-p22.2Početak16,409,503 bp[1]
Kraj16,870,843 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za BNC2
Genomska lokacija za BNC2
Bend4|4 C3- C4Početak84,193,332 bp[2]
Kraj84,593,512 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija vezivanje iona metala
vezivanje sa DNK
nucleic acid binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta jedro
nukleoplazma
ćelijska membrana
citosol
Biološki proces tongue development
endochondral bone growth
GO:0009373 regulation of transcription, DNA-templated
mesenchyme development
roof of mouth development
transcription, DNA-templated
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_017637
NM_001317939
NM_001317940

NM_172870
NM_001369081
NM_001369082
NM_001369083
NM_001369084

RefSeq (bjelančevina)

NP_001304868
NP_001304869
NP_060107

NP_766458
NP_001356010
NP_001356011
NP_001356012
NP_001356013

Lokacija (UCSC)Chr 9: 16.41 – 16.87 MbChr 4: 84.19 – 84.59 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein cinovog prsta bazonuklin-2 je protein koji je kod ljudi kodiran genom BNC2.[5][6] Nedavno se pokazalo da BCN2 utpče na razinu pigmentacije kože u Evropljana.[7] Genomska regija koja obuhvata gen BCN2 ima 60% DNK sekvence neandertalaca.[8]

Aminokiselinska sekvenca

[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.099 aminokiselina, а molekulska težina 122.330 Da.[9]

1020304050
MAHLGPTPPPHSLNYKSEDRLSEQDWPAYFKVPCCGVDTSQIESEEAEVD
VRERETQRDREPKRARDLTLRDSCTDNSMQFGTRTTTAEPGFMGTWQNAD
TNLLFRMSQQAIRCTLVNCTCECFQPGKINLRTCDQCKHGWVAHALDKLS
TQHLYHPTQVEIVQSNVVFDISSLMLYGTQAVPVRLKILLDRLFSVLKQE
EVLHILHGLGWTLRDYVRGYILQDAAGKVLDRWAIMSREEEIITLQQFLR
FGETKSIVELMAIQEKEGQAVAVPSSKTDSDIRTFIESNNRTRSPSLLAH
LENSNPSSIHHFENIPNSLAFLLPFQYINPVSAPLLGLPPNGLLLEQPGL
RLREPSLSTQNEYNESSESEVSPTPYKNDQTPNRNALTSITNVEPKTEPA
CVSPIQNSAPVSDLTKTEHPKSSFRIHRMRRMGSASRKGRVFCNACGKTF
YDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNPRLHMP
MLRNNRDKDLIRATSGAATPVIASTKSNLALTSPGRPPMGFTTPPLDPVL
QNPLPSQLVFSGLKTVQPVPPFYRSLLTPGEMVSPPTSLPTSPIIPTSGT
IEQHPPPPSEPVVPAVMMATHEPSADLAPKKKPRKSSMPVKIEKEIIDTA
DEFDDEDDDPNDGGAVVNDMSHDNHCHSQEEMSPGMSVKDFSKHNRTRCI
SRTEIRRADSMTSEDQEPERDYENESESSEPKLGEESMEGDEHIHSEVSE
KVLMNSERPDENHSEPSHQDVIKVKEEFTDPTYDMFYMSQYGLYNGGGAS
MAALHESFTSSLNYGSPQKFSPEGDLCSSPDPKICYVCKKSFKSSYSVKL
HYRNVHLKEMHVCTVAGCNAAFPSRRSRDRHSANINLHRKLLTKELDDMG
LDSSQPSLSKDLRDEFLVKIYGAQHPMGLDVREDASSPAGTEDSHLNGYG
RGMAEDYMVLDLSTTSSLQSSSSIHSSRESDAGSDEGILLDDIDGASDSG
ESAHKAEAPALPGSLGAEVSGSLMFSSLSGSNGGIMCNICHKMYSNKGTL
RVHYKTVHLREMHKCKVPGCNMMFSSVRSRNRHSQNPNLHKNIPFTSVD

Također pogledajte

[uredi | uredi izvor]

Reference

[uredi | uredi izvor]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173068 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028487 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (Jan 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  6. ^ "Entrez Gene: BNC2 basonuclin 2".
  7. ^ Jacobs LC, Wollstein A, Lao O, Hofman A, Klaver CC, Uitterlinden AG, Nijsten T, Kayser M, Liu F (Feb 2013). "Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans". Human Genetics. 132 (2): 147–58. doi:10.1007/s00439-012-1232-9. PMID 23052946. S2CID 6057298.
  8. ^ Vattathil S, Akey JM (Oct 2015). "Small Amounts of Archaic Admixture Provide Big Insights into Human History". Cell. 163 (2): 281–4. doi:10.1016/j.cell.2015.09.042. PMID 26451479.
  9. ^ "UniProt, Q6ZN30". Pristupljeno 6. 9. 2021.

Dopunska literatura

[uredi | uredi izvor]