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TGFBR3

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TGFBR3
Identifikatori
AliasiTGFBR3
Vanjski ID-jeviOMIM: 600742 MGI: 104637 HomoloGene: 2436 GeneCards: TGFBR3
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za TGFBR3
Genomska lokacija za TGFBR3
Bend1p22.1Početak91,680,343 bp[1]
Kraj91,906,335 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za TGFBR3
Genomska lokacija za TGFBR3
Bend5|5 E5Početak107,254,436 bp[2]
Kraj107,437,495 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija transforming growth factor beta receptor binding
heparin binding
activin binding
transforming growth factor beta receptor activity, type III
transforming growth factor beta-activated receptor activity
SMAD binding
PDZ domain binding
coreceptor activity
fibroblast growth factor binding
type II transforming growth factor beta receptor binding
GO:0001948, GO:0016582 vezivanje za proteine
glycosaminoglycan binding
transforming growth factor beta binding
Ćelijska komponenta Egzosom
extracellular region
citoplazma
integral component of membrane
inhibin-betaglycan-ActRII complex
integral component of plasma membrane
membrana
cell surface
receptor complex
ćelijska membrana
external side of plasma membrane
Vanćelijsko
GO:0005578 Vanćelijski matriks
Biološki proces response to hypoxia
heart trabecula formation
GO:0007243 intracellular signal transduction
liver development
animal organ regeneration
definitive erythrocyte differentiation
BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
regulation of protein binding
heart morphogenesis
transforming growth factor beta receptor complex assembly
cardiac epithelial to mesenchymal transition
pathway-restricted SMAD protein phosphorylation
response to follicle-stimulating hormone
ventricular cardiac muscle tissue morphogenesis
roof of mouth development
cardiac muscle cell proliferation
response to prostaglandin E
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of epithelial cell proliferation
Ćelijska migracija
definitive hemopoiesis
epithelial to mesenchymal transition
response to luteinizing hormone
GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor
transforming growth factor beta receptor signaling pathway
epicardium-derived cardiac fibroblast cell development
ventricular septum morphogenesis
regulation of ERK1 and ERK2 cascade
ventricular compact myocardium morphogenesis
heart trabecula morphogenesis
positive regulation of cardiac muscle cell proliferation
regulation of JNK cascade
muscular septum morphogenesis
vasculogenesis involved in coronary vascular morphogenesis
outflow tract morphogenesis
secondary palate development
GO:0034622 protein-containing complex assembly
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001195683
NM_001195684
NM_003243

NM_011578

RefSeq (bjelančevina)

NP_001182612
NP_001182613
NP_003234

NP_035708

Lokacija (UCSC)Chr 1: 91.68 – 91.91 MbChr 5: 107.25 – 107.44 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Betaglikan, znan i kao receptor III transformirajućeg faktora rasta, jest površinskoćelijski hondroitin-sulfatni/heparan-sulfateni proteoglikan. To je protein koji je kod ljudi kodiran genom TGFBR3 sa hromosoma 1.

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 851 aminokiselina, a molekulska težina 93.499 Da.[5]

1020304050
MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALMESFTVLS
GCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSV
VFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEE
RNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIG
KNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQV
DITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSI
GFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANR
FHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGG
LPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDI
ALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLES
PLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGF
PGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNT
DLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRM
SHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSL
LFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTK
PLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGAL
LTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSST
A

Funkcija

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Betaglikan se vezuje za različite članove natporodice TGF-beta liganda preko svog jezgarnog proteina i bFGF preko svojih heparan-sulfatnih lanaca. Nije uključen direktno u TGF-beta transdukciju signala, ali vezivanjem za različite članove natporodice TGF-beta na površini ćelije djeluje kao rezervoar liganda za receptore TGF-beta.[6][7]

Također pogledajte

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069702 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029287 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "UniProt, Q03167" (jezik: en.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)
  6. ^ Andres JL, Stanley K, et al. (1989). "Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta". J. Cell Biol. 109 (6 (Pt 1)): 3137–3145. doi:10.1083/jcb.109.6.3137. PMC 2115961. PMID 2592419.
  7. ^ Andres JL, DeFalcis D, et al. (1992). "Binding of two growth factor families to separate domains of the proteoglycan betaglycan". J. Biol. Chem. 267 (9): 5927–5930. doi:10.1016/S0021-9258(18)42643-9. PMID 1556106.

Dopunska literatura

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Vanjski linkovi

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Šablon:Natporodica TGFβ receptorskih modulatora