SOX9 |
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![](https://cdn.statically.io/img/upload.wikimedia.org/wikipedia/commons/thumb/a/ab/Protein_SOX9_PDB_1S9M.png/250px-Protein_SOX9_PDB_1S9M.png) |
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Dynodwyr |
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Cyfenwau | SOX9, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9, SRY-box transcription factor 9 |
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Dynodwyr allanol | OMIM: 608160 HomoloGene: 294 GeneCards: SOX9 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • core promoter sequence-specific DNA binding • protein kinase activity • protein kinase A catalytic subunit binding • beta-catenin binding • pre-mRNA intronic binding • chromatin binding • GO:0001948, GO:0016582 protein binding • DNA binding • sequence-specific DNA binding • GO:0000975 transcription cis-regulatory region binding • bHLH transcription factor binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Cydrannau o'r gell | • cnewyllyn cell • transcription regulator complex • nucleoplasm • GO:0009327 protein-containing complex
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Prosesau biolegol | • skeletal system development • cellular response to retinoic acid • bronchus cartilage development • positive regulation of protein phosphorylation • heart valve development • limb bud formation • GO:1903364 positive regulation of protein catabolic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • ureter morphogenesis • negative regulation of immune system process • chondrocyte development • positive regulation of cell proliferation involved in heart morphogenesis • oligodendrocyte differentiation • chondrocyte hypertrophy • prostate gland development • lung smooth muscle development • mammary gland development • negative regulation of ossification • negative regulation of photoreceptor cell differentiation • cellular response to mechanical stimulus • intrahepatic bile duct development • regulation of cell adhesion • negative regulation of chondrocyte differentiation • positive regulation of mesenchymal cell proliferation • astrocyte fate commitment • positive regulation of chondrocyte differentiation • spermatogenesis • prostate gland morphogenesis • negative regulation of epithelial cell proliferation • lung epithelial cell differentiation • chondrocyte differentiation involved in endochondral bone morphogenesis • negative regulation of canonical Wnt signaling pathway • endocrine pancreas development • negative regulation of cell population proliferation • regulation of apoptotic process • cellular response to transforming growth factor beta stimulus • negative regulation of mesenchymal cell apoptotic process • chromatin remodeling • negative regulation of myoblast differentiation • positive regulation of branching involved in ureteric bud morphogenesis • cell fate commitment • GO:0009373 regulation of transcription, DNA-templated • epidermal growth factor receptor signaling pathway • ossification • regulation of cell proliferation involved in tissue homeostasis • ureter smooth muscle cell differentiation • ERK1 and ERK2 cascade • notochord development • positive regulation of epithelial cell migration • Sertoli cell differentiation • male sex determination • negative regulation of gene expression • transcription, DNA-templated • metanephric nephron tubule formation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • regulation of branching involved in lung morphogenesis • ureter urothelium development • branching involved in ureteric bud morphogenesis • cartilage development • Harderian gland development • positive regulation of kidney development • central nervous system development • heart valve formation • positive regulation of cartilage development • tissue homeostasis • metanephric tubule development • negative regulation of biomineral tissue development • endochondral bone morphogenesis • trachea cartilage development • male germ-line sex determination • lacrimal gland development • Notch signaling pathway • hair follicle development • cell differentiation • ureter development • regulation of cell cycle process • male gonad development • positive regulation of epithelial cell proliferation • cell fate specification • intestinal epithelial structure maintenance • positive regulation of extracellular matrix assembly • extracellular matrix organization • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • Sertoli cell development • positive regulation of mesenchymal stem cell differentiation • retina development in camera-type eye • cellular response to interleukin-1 • epithelial to mesenchymal transition • homeostasis of number of cells within a tissue • GO:0045996 negative regulation of transcription, DNA-templated • cAMP-mediated signaling • cartilage condensation • positive regulation of male gonad development • nucleosome assembly • negative regulation of bone mineralization • morphogenesis of a branching epithelium • neural crest cell development • protein kinase B signaling • somatic stem cell population maintenance • otic vesicle formation • otic vesicle development • endocardial cushion morphogenesis • cellular response to epidermal growth factor stimulus • positive regulation of epithelial cell differentiation • renal vesicle induction • GO:1901313 positive regulation of gene expression • regulation of epithelial cell proliferation involved in lung morphogenesis • regulation of cell population proliferation • heart valve morphogenesis • cytoskeleton organization • cochlea morphogenesis • positive regulation of cell population proliferation • epithelial cell proliferation involved in prostatic bud elongation • retinal rod cell differentiation • protein localization to nucleus • regulation of cell differentiation • positive regulation of phosphatidylinositol 3-kinase signaling • cellular response to heparin • negative regulation of epithelial cell differentiation • epithelial tube branching involved in lung morphogenesis • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of pri-miRNA transcription by RNA polymerase II • chondrocyte differentiation • neural crest cell fate specification • cellular response to BMP stimulus • cell-cell adhesion • transcription initiation from RNA polymerase II promoter • GO:0034622 protein-containing complex assembly • anterior head development • morphogenesis of an epithelium • aortic valve morphogenesis • regulation of gene expression
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn SOX9 yw SOX9 a elwir hefyd yn SRY-box 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q24.3.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SOX9.
- CMD1
- SRA1
- CMPD1
- SRXX2
- SRXY10
- "Expression and Clinical Significance of SOX9 in Renal Cell Carcinoma, Bladder Cancer and Penile Cancer. ". Oncol Res Treat. 2017. PMID 28118628.
- "Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China. ". Biomed Res Int. 2016. PMID 28090537.
- "SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types. ". PLoS One. 2017. PMID 29121666.
- "Tomo-Seq Identifies SOX9 as a Key Regulator of Cardiac Fibrosis During Ischemic Injury. ". Circulation. 2017. PMID 28724751.
- "Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells.". Oncol Res. 2017. PMID 28277188.