Anisindione (brand name Miradon) is a synthetic anticoagulant and an 1,3-indandione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins.[1]

Anisindione
Structural formula of anisindione
Ball-and-stick model of the anisindione molecule
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
Oral
ATC code
  • none
Identifiers
  • 2-(4-methoxyphenyl)indene-1,3-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.003.806 Edit this at Wikidata
Chemical and physical data
FormulaC16H12O3
Molar mass252.269 g·mol−1
3D model (JSmol)
  • O=C2c1ccccc1C(=O)C2c3ccc(OC)cc3
  • InChI=1S/C16H12O3/c1-19-11-8-6-10(7-9-11)14-15(17)12-4-2-3-5-13(12)16(14)18/h2-9,14H,1H3 checkY
  • Key:XRCFXMGQEVUZFC-UHFFFAOYSA-N checkY
  (verify)

References

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  1. ^ Matschinske J, Salgado-Albarrán M, Sadegh S, Bongiovanni D, Baumbach J, Blumenthal DB (November 2020). "Individuating Possibly Repurposable Drugs and Drug Targets for COVID-19 Treatment Through Hypothesis-Driven Systems Medicine Using CoVex". Assay and Drug Development Technologies. 18 (8): 348–355. doi:10.1089/adt.2020.1010. PMC 7703307. PMID 33164550.