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Mammalian protein found in Homo sapiens
ITGA2B Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DPK , 1DPQ , 1KUP , 1KUZ , 1M8O , 1S4W , 1TYE , 2K1A , 2K9J , 2KNC , 2MTP , 2VC2 , 2VDK , 2VDL , 2VDM , 2VDN , 2VDO , 2VDP , 2VDQ , 2VDR , 3FCS , 3FCU , 3NID , 3NIF , 3NIG , 3T3M , 3T3P , 3ZDX , 3ZDY , 3ZDZ , 3ZE0 , 3ZE1 , 3ZE2 , 4CAK , 4Z7O , 4Z7Q , 5HDB , 4Z7N
Identifiers Aliases ITGA2B , BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1External IDs OMIM : 607759 ; MGI : 96601 ; HomoloGene : 37304 ; GeneCards : ITGA2B ; OMA :ITGA2B - orthologs Wikidata
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene . ITGA2B, also known as CD 41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered.[5] In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[6]
Interactions [ edit ]
ITGA2B has been shown to interact with AUP1 [7] and CLNS1A .[8]
See also [ edit ]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000005961 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034664 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Šimčíková D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases" . Scientific Reports . 9 (1): 18577. Bibcode :2019NatSR...918577S . doi :10.1038/s41598-019-54976-4 . PMC 6901466 . PMID 31819097 .
^ "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)" .
^ Kato A, Kawamata Norihiko, Tamayose Kenji, Egashira Motoki, Miura Rika, Fujimura Tsutomu, Murayama Kimie, Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3" . J. Biol. Chem . 277 (32). United States: 28934–41. doi :10.1074/jbc.M204340200 . ISSN 0021-9258 . PMID 12042322 .
^ Larkin D, Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation" . J. Biol. Chem . 279 (26). United States: 27286–93. doi :10.1074/jbc.M402159200 . ISSN 0021-9258 . PMID 15075326 .
Further reading [ edit ]
Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization". Thromb. Haemost . 72 (4): 492–502. PMID 7878622 .
Naik UP, Parise LV (1997). "Structure and function of platelet alpha IIb beta 3". Curr. Opin. Hematol . 4 (5): 317–22. doi :10.1097/00062752-199704050-00004 . PMID 9288464 .
Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol . 8 (10): 390–6. doi :10.1016/S0962-8924(98)01344-0 . PMID 9789327 .
Lincoff AM (1998). "Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization". Am. J. Cardiol . 82 (8B): 36P–42P. doi :10.1016/S0002-9149(98)00662-6 . PMID 9809890 .
Bennett JS (2001). "Platelet-fibrinogen interactions". Ann. N. Y. Acad. Sci . 936 (1): 340–54. Bibcode :2001NYASA.936..340B . doi :10.1111/j.1749-6632.2001.tb03521.x . PMID 11460491 . S2CID 25431334 .
Plow EF, Cierniewski CS, Xiao Z, et al. (2002). "AlphaIIbbeta3 and its antagonism at the new millennium". Thromb. Haemost . 86 (1): 34–40. doi :10.1055/s-0037-1616198 . PMID 11487023 . S2CID 74389210 .
Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism" . Arterioscler. Thromb. Vasc. Biol . 23 (6): 945–52. doi :10.1161/01.ATV.0000066686.46338.F1 . PMID 12637342 .
Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des . 10 (14): 1567–76. doi :10.2174/1381612043384682 . PMID 15134555 .
Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets" . J. Thromb. Haemost . 3 (8): 1752–62. doi :10.1111/j.1538-7836.2005.01429.x . PMID 16102042 . S2CID 42666713 .
Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3" . J. Clin. Invest . 115 (12): 3363–9. doi :10.1172/JCI26989 . PMC 1297263 . PMID 16322781 .
Ma YQ, Qin J, Plow EF (2007). "Platelet integrin alpha(IIb)beta(3): activation mechanisms". J. Thromb. Haemost . 5 (7): 1345–52. doi :10.1111/j.1538-7836.2007.02537.x . PMID 17635696 . S2CID 12983526 .
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