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NPR1

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NPR1
Identifiers
AliasesNPR1, ANPRA, ANPa, GUC2A, GUCY2A, NPRA, natriuretic peptide receptor 1
External IDsOMIM: 108960; MGI: 97371; HomoloGene: 37367; GeneCards: NPR1; OMA:NPR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000906

NM_008727

RefSeq (protein)

NP_000897

NP_032753

Location (UCSC)Chr 1: 153.68 – 153.69 MbChr 3: 90.36 – 90.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

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NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).[5]

It is localized in the kidney[6] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169418Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027931Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)".
  6. ^ a b BioGPS > NPR1 Retrieved Nov 2010 Archived November 27, 2010, at the Wayback Machine

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.