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POLE4

From Wikipedia, the free encyclopedia
POLE4
Identifiers
AliasesPOLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
External IDsOMIM: 607269; MGI: 1914229; HomoloGene: 41339; GeneCards: POLE4; OMA:POLE4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019896

NM_025882
NM_001370295

RefSeq (protein)

NP_063949

NP_080158
NP_001357224

Location (UCSC)Chr 2: 74.96 – 74.97 MbChr 6: 82.6 – 82.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.[5]

Function

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POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115350Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030042Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Polymerase (DNA-directed), epsilon 4, accessory subunit".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.