Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 23:46, 9 November 2007 (UTC)[edit]
Proteins without matches (22)[edit]
Proteins with a High Potential Match (3)[edit]
Created (11)[edit]
Manual Inspection (Page not found) (14)[edit]
Protein Status Grid - Date: 23:46, 9 November 2007 (UTC)[edit]
Vebose Log - Date: 23:46, 9 November 2007 (UTC)[edit]
- INFO: Beginning work on ACP1... {November 9, 2007 3:06:48 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ACP1 image.jpg {November 9, 2007 3:07:58 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:08:13 PM PST}
- CREATED: Created new protein page: ACP1 {November 9, 2007 3:08:21 PM PST}
- INFO: Beginning work on APTX... {November 9, 2007 3:37:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:38:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Aprataxin
| HGNCid = 15984
| Symbol = APTX
| AltSymbols =; AOA; AOA1; AXA1; EAOH; EOAHA; FHA-HIT; FLJ20157; MGC1072
| OMIM = 606350
| ECnumber =
| Homologene = 41634
| MGIid = 1913658
| GeneAtlas_image1 = PBB_GE_APTX_218527_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000012 |text = single strand break repair}} {{GNF_GO|id=GO:0006284 |text = base-excision repair}} {{GNF_GO|id=GO:0008219 |text = cell death}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 54840
| Hs_Ensembl = ENSG00000137074
| Hs_RefseqProtein = NP_060162
| Hs_RefseqmRNA = NM_017692
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 32962609
| Hs_GenLoc_end = 33015110
| Hs_Uniprot = Q7Z2E3
| Mm_EntrezGene = 66408
| Mm_Ensembl = ENSMUSG00000028411
| Mm_RefseqmRNA = NM_001025445
| Mm_RefseqProtein = NP_001020616
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 40874906
| Mm_GenLoc_end = 40891858
| Mm_Uniprot = Q7TQC5
}}
}}
'''Aprataxin''', also known as '''APTX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.<ref>{{cite web | title = Entrez Gene: APTX aprataxin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54840| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HTR4... {November 9, 2007 3:09:14 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:10:29 PM PST}
- CREATED: Created new protein page: HTR4 {November 9, 2007 3:10:37 PM PST}
- INFO: Beginning work on ID3... {November 9, 2007 3:10:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:11:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
| HGNCid = 5362
| Symbol = ID3
| AltSymbols =; HEIR-1
| OMIM = 600277
| ECnumber =
| Homologene = 1633
| MGIid = 96398
| GeneAtlas_image1 = PBB_GE_ID3_207826_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}} {{GNF_GO|id=GO:0043433 |text = negative regulation of transcription factor activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3399
| Hs_Ensembl = ENSG00000117318
| Hs_RefseqProtein = NP_002158
| Hs_RefseqmRNA = NM_002167
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 23756996
| Hs_GenLoc_end = 23758872
| Hs_Uniprot = Q02535
| Mm_EntrezGene = 15903
| Mm_Ensembl = ENSMUSG00000007872
| Mm_RefseqmRNA = NM_008321
| Mm_RefseqProtein = NP_032347
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 135415900
| Mm_GenLoc_end = 135417466
| Mm_Uniprot = Q545W1
}}
}}
'''Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein''', also known as '''ID3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3399| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ITGAX... {November 9, 2007 3:12:18 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ITGAX image.jpg {November 9, 2007 3:12:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:13:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ITGAX_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n3y.
| PDB = {{PDB2|1n3y}}
| Name = Integrin, alpha X (complement component 3 receptor 4 subunit)
| HGNCid = 6152
| Symbol = ITGAX
| AltSymbols =; CD11C
| OMIM = 151510
| ECnumber =
| Homologene = 55493
| MGIid = 96609
| GeneAtlas_image1 = PBB_GE_ITGAX_210184_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3687
| Hs_Ensembl = ENSG00000140678
| Hs_RefseqProtein = XP_001127869
| Hs_RefseqmRNA = XM_001127869
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 31274010
| Hs_GenLoc_end = 31301819
| Hs_Uniprot = P20702
| Mm_EntrezGene = 16411
| Mm_Ensembl = ENSMUSG00000030789
| Mm_RefseqmRNA = NM_021334
| Mm_RefseqProtein = NP_067309
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 127920710
| Mm_GenLoc_end = 127941804
| Mm_Uniprot = Q3TD13
}}
}}
'''Integrin, alpha X (complement component 3 receptor 4 subunit)''', also known as '''ITGAX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.<ref>{{cite web | title = Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3687| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Stewart M, Thiel M, Hogg N |title=Leukocyte integrins. |journal=Curr. Opin. Cell Biol. |volume=7 |issue= 5 |pages= 690-6 |year= 1996 |pmid= 8573344 |doi= }}
*{{cite journal | author=Steinman RM, Pack M, Inaba K |title=Dendritic cells in the T-cell areas of lymphoid organs. |journal=Immunol. Rev. |volume=156 |issue= |pages= 25-37 |year= 1997 |pmid= 9176697 |doi= }}
*{{cite journal | author=Córbi AL, Lopéz-Rodríguez C |title=CD11c integrin gene promoter activity during myeloid differentiation. |journal=Leuk. Lymphoma |volume=25 |issue= 5-6 |pages= 415-25 |year= 1997 |pmid= 9250811 |doi= }}
*{{cite journal | author=Ugarova TP, Yakubenko VP |title=Recognition of fibrinogen by leukocyte integrins. |journal=Ann. N. Y. Acad. Sci. |volume=936 |issue= |pages= 368-85 |year= 2001 |pmid= 11460493 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KIR3DL1... {November 9, 2007 3:13:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:14:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
| HGNCid = 6338
| Symbol = KIR3DL1
| AltSymbols =; KIR; AMB11; CD158E1; CD158E1/2; CD158E2; CL-11; CL-2; KIR-G1; KIR3DL1/2V; KIR3DS1; MGC119726; MGC119728; MGC126589; MGC126591; NKAT10; NKAT3; NKB1; NKB1B
| OMIM = 604946
| ECnumber =
| Homologene = 77448
| MGIid = 3612791
| GeneAtlas_image1 = PBB_GE_KIR3DL1_211389_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_KIR3DL1_207313_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_KIR3DL1_211687_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0030109 |text = HLA-B specific inhibitory MHC class I receptor activity}} {{GNF_GO|id=GO:0032393 |text = MHC class I receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0030101 |text = natural killer cell activation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3811
| Hs_Ensembl = ENSG00000167633
| Hs_RefseqProtein = NP_037421
| Hs_RefseqmRNA = NM_013289
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 60019741
| Hs_GenLoc_end = 60034044
| Hs_Uniprot = P43629
| Mm_EntrezGene = 245615
| Mm_Ensembl = ENSMUSG00000057439
| Mm_RefseqmRNA = NM_177748
| Mm_RefseqProtein = NP_808416
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 131795127
| Mm_GenLoc_end = 131815400
| Mm_Uniprot = Q673W3
}}
}}
'''Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1''', also known as '''KIR3DL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.<ref>{{cite web | title = Entrez Gene: KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3811| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Selvakumar A, Steffens U, Dupont B |title=Polymorphism and domain variability of human killer cell inhibitory receptors. |journal=Immunol. Rev. |volume=155 |issue= |pages= 183-96 |year= 1997 |pmid= 9059894 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KLK2... {November 9, 2007 3:14:58 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:16:51 PM PST}
- CREATED: Created new protein page: KLK2 {November 9, 2007 3:17:01 PM PST}
- INFO: Beginning work on LAMC1... {November 9, 2007 3:17:01 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LAMC1 image.jpg {November 9, 2007 3:18:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:18:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LAMC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1klo.
| PDB = {{PDB2|1klo}}, {{PDB2|1npe}}, {{PDB2|1tle}}
| Name = Laminin, gamma 1 (formerly LAMB2)
| HGNCid = 6492
| Symbol = LAMC1
| AltSymbols =; LAMB2; MGC87297
| OMIM = 150290
| ECnumber =
| Homologene = 1724
| MGIid = 99914
| GeneAtlas_image1 = PBB_GE_LAMC1_200771_at_tn.png
| GeneAtlas_image2 = PBB_GE_LAMC1_200770_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005606 |text = laminin-1 complex}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007492 |text = endoderm development}} {{GNF_GO|id=GO:0050679 |text = positive regulation of epithelial cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3915
| Hs_Ensembl = ENSG00000135862
| Hs_RefseqProtein = NP_002284
| Hs_RefseqmRNA = NM_002293
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 181259176
| Hs_GenLoc_end = 181381350
| Hs_Uniprot = P11047
| Mm_EntrezGene = 226519
| Mm_Ensembl = ENSMUSG00000026478
| Mm_RefseqmRNA = NM_010683
| Mm_RefseqProtein = NP_034813
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 154981138
| Mm_GenLoc_end = 155095004
| Mm_Uniprot = Q3TRH4
}}
}}
'''Laminin, gamma 1 (formerly LAMB2)''', also known as '''LAMC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.<ref>{{cite web | title = Entrez Gene: LAMC1 laminin, gamma 1 (formerly LAMB2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3915| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ljubimova JY, Fujita M, Khazenzon NM, ''et al.'' |title=Changes in laminin isoforms associated with brain tumor invasion and angiogenesis. |journal=Front. Biosci. |volume=11 |issue= |pages= 81-8 |year= 2006 |pmid= 16146715 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MAP3K11... {November 9, 2007 3:20:58 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:22:20 PM PST}
- CREATED: Created new protein page: MAP3K11 {November 9, 2007 3:22:32 PM PST}
- INFO: Beginning work on MSX1... {November 9, 2007 3:22:32 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MSX1 image.jpg {November 9, 2007 3:23:16 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:23:40 PM PST}
- CREATED: Created new protein page: MSX1 {November 9, 2007 3:23:50 PM PST}
- INFO: Beginning work on MSX2... {November 9, 2007 3:23:50 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MSX2 image.jpg {November 9, 2007 3:25:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:25:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MSX2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ig7.
| PDB = {{PDB2|1ig7}}
| Name = Msh homeobox 2
| HGNCid = 7392
| Symbol = MSX2
| AltSymbols =; CRS2; FPP; HOX8; MSH; PFM; PFM1
| OMIM = 123101
| ECnumber =
| Homologene = 1837
| MGIid = 97169
| GeneAtlas_image1 = PBB_GE_MSX2_205555_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MSX2_210319_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4488
| Hs_Ensembl = ENSG00000120149
| Hs_RefseqProtein = NP_002440
| Hs_RefseqmRNA = NM_002449
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 174084208
| Hs_GenLoc_end = 174090507
| Hs_Uniprot = P35548
| Mm_EntrezGene = 17702
| Mm_Ensembl = ENSMUSG00000021469
| Mm_RefseqmRNA = NM_013601
| Mm_RefseqProtein = NP_038629
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 53475420
| Mm_GenLoc_end = 53480608
| Mm_Uniprot = Q3UZH5
}}
}}
'''Msh homeobox 2''', also known as '''MSX2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.<ref>{{cite web | title = Entrez Gene: MSX2 msh homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4488| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MT2A... {November 9, 2007 3:25:34 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MT2A image.jpg {November 9, 2007 3:26:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:26:55 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MT2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mhu.
| PDB = {{PDB2|1mhu}}, {{PDB2|1mrb}}, {{PDB2|1mrt}}, {{PDB2|2mhu}}
| Name = Metallothionein 2A
| HGNCid = 7406
| Symbol = MT2A
| AltSymbols =; MT2
| OMIM = 156360
| ECnumber =
| Homologene = 48388
| MGIid = 97172
| GeneAtlas_image1 = PBB_GE_MT2A_212185_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006878 |text = cellular copper ion homeostasis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4502
| Hs_Ensembl = ENSG00000125148
| Hs_RefseqProtein = NP_005944
| Hs_RefseqmRNA = NM_005953
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 55199997
| Hs_GenLoc_end = 55200909
| Hs_Uniprot = P02795
| Mm_EntrezGene = 17750
| Mm_Ensembl = ENSMUSG00000031762
| Mm_RefseqmRNA = NM_008630
| Mm_RefseqProtein = NP_032656
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 97061913
| Mm_GenLoc_end = 97062691
| Mm_Uniprot = P02798
}}
}}
'''Metallothionein 2A''', also known as '''MT2A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OAS1... {November 9, 2007 3:26:55 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:28:06 PM PST}
- CREATED: Created new protein page: OAS1 {November 9, 2007 3:28:14 PM PST}
- INFO: Beginning work on ODC1... {November 9, 2007 3:28:14 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ODC1 image.jpg {November 9, 2007 3:28:56 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:29:05 PM PST}
- CREATED: Created new protein page: ODC1 {November 9, 2007 3:29:12 PM PST}
- INFO: Beginning work on PDK1... {November 9, 2007 3:30:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:31:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pyruvate dehydrogenase kinase, isozyme 1
| HGNCid = 8809
| Symbol = PDK1
| AltSymbols =;
| OMIM = 602524
| ECnumber =
| Homologene = 20576
| MGIid = 1926119
| GeneAtlas_image1 = PBB_GE_PDK1_206686_at_tn.png
| Function = {{GNF_GO|id=GO:0004673 |text = protein histidine kinase activity}} {{GNF_GO|id=GO:0004740 |text = [pyruvate dehydrogenase (lipoamide)] kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0018106 |text = peptidyl-histidine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5163
| Hs_Ensembl = ENSG00000152256
| Hs_RefseqProtein = NP_002601
| Hs_RefseqmRNA = NM_002610
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 173129025
| Hs_GenLoc_end = 173172108
| Hs_Uniprot = Q15118
| Mm_EntrezGene = 228026
| Mm_Ensembl = ENSMUSG00000006494
| Mm_RefseqmRNA = NM_172665
| Mm_RefseqProtein = NP_766253
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 71674063
| Mm_GenLoc_end = 71702840
| Mm_Uniprot = Q3U5E5
}}
}}
'''Pyruvate dehydrogenase kinase, isozyme 1''', also known as '''PDK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.<ref>{{cite web | title = Entrez Gene: PDK1 pyruvate dehydrogenase kinase, isozyme 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5163| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sugden MC, Holness MJ |title=Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=284 |issue= 5 |pages= E855-62 |year= 2003 |pmid= 12676647 |doi= 10.1152/ajpendo.00526.2002 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PEBP1... {November 9, 2007 3:29:12 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PEBP1 image.jpg {November 9, 2007 3:30:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:30:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PEBP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a44.
| PDB = {{PDB2|1a44}}, {{PDB2|1b7a}}, {{PDB2|1bd9}}, {{PDB2|1beh}}
| Name = Phosphatidylethanolamine binding protein 1
| HGNCid = 8630
| Symbol = PEBP1
| AltSymbols =; PBP; HCNP; PEBP; RKIP
| OMIM = 604591
| ECnumber =
| Homologene = 37637
| MGIid = 1344408
| GeneAtlas_image1 = PBB_GE_PEBP1_210825_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PEBP1_211941_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PEBP1_205353_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0008429 |text = phosphatidylethanolamine binding}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5037
| Hs_Ensembl = ENSG00000089220
| Hs_RefseqProtein = NP_002558
| Hs_RefseqmRNA = NM_002567
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 117058253
| Hs_GenLoc_end = 117067770
| Hs_Uniprot = P30086
| Mm_EntrezGene = 23980
| Mm_Ensembl = ENSMUSG00000032959
| Mm_RefseqmRNA = NM_018858
| Mm_RefseqProtein = NP_061346
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 117543684
| Mm_GenLoc_end = 117548617
| Mm_Uniprot = Q3TGC5
}}
}}
'''Phosphatidylethanolamine binding protein 1''', also known as '''PEBP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schoentgen F, Jollès P |title=From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site. |journal=FEBS Lett. |volume=369 |issue= 1 |pages= 22-6 |year= 1995 |pmid= 7641877 |doi= }}
*{{cite journal | author=Ojika K, Mitake S, Tohdoh N, ''et al.'' |title=Hippocampal cholinergic neurostimulating peptides (HCNP). |journal=Prog. Neurobiol. |volume=60 |issue= 1 |pages= 37-83 |year= 2000 |pmid= 10622376 |doi= }}
*{{cite journal | author=Odabaei G, Chatterjee D, Jazirehi AR, ''et al.'' |title=Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis. |journal=Adv. Cancer Res. |volume=91 |issue= |pages= 169-200 |year= 2004 |pmid= 15327891 |doi= 10.1016/S0065-230X(04)91005-6 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPP2R2B... {November 9, 2007 3:31:19 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:32:28 PM PST}
- CREATED: Created new protein page: PPP2R2B {November 9, 2007 3:32:39 PM PST}
- INFO: Beginning work on PSMB10... {November 9, 2007 3:32:39 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:33:14 PM PST}
- CREATED: Created new protein page: PSMB10 {November 9, 2007 3:33:23 PM PST}
- INFO: Beginning work on PSMD11... {November 9, 2007 3:33:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:34:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
| HGNCid = 9556
| Symbol = PSMD11
| AltSymbols =; MGC3844; S9; p44.5
| OMIM = 604449
| ECnumber =
| Homologene = 2108
| MGIid = 1916327
| GeneAtlas_image1 = PBB_GE_PSMD11_208777_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5717
| Hs_Ensembl = ENSG00000108671
| Hs_RefseqProtein = NP_002806
| Hs_RefseqmRNA = NM_002815
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 27795615
| Hs_GenLoc_end = 27832154
| Hs_Uniprot = O00231
| Mm_EntrezGene = 69077
| Mm_Ensembl = ENSMUSG00000017428
| Mm_RefseqmRNA = NM_178616
| Mm_RefseqProtein = NP_848731
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 80244860
| Mm_GenLoc_end = 80287789
| Mm_Uniprot = Q3THG2
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11''', also known as '''PSMD11''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator.<ref>{{cite web | title = Entrez Gene: PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5717| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTX3... {November 9, 2007 3:34:04 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:34:36 PM PST}
- CREATED: Created new protein page: PTX3 {November 9, 2007 3:34:44 PM PST}
- INFO: Beginning work on PVR... {November 9, 2007 3:34:44 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PVR image.jpg {November 9, 2007 3:36:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:37:01 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PVR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dgi.
| PDB = {{PDB2|1dgi}}, {{PDB2|1nn8}}
| Name = Poliovirus receptor
| HGNCid = 9705
| Symbol = PVR
| AltSymbols =; CD155; HVED; NECL5; Necl-5; PVS; TAGE4
| OMIM = 173850
| ECnumber =
| Homologene = 9672
| MGIid =
| GeneAtlas_image1 = PBB_GE_PVR_214443_at_tn.png
| GeneAtlas_image2 = PBB_GE_PVR_212662_at_tn.png
| GeneAtlas_image3 = PBB_GE_PVR_214444_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0016477 |text = cell migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5817
| Hs_Ensembl = ENSG00000073008
| Hs_RefseqProtein = NP_006496
| Hs_RefseqmRNA = NM_006505
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 49839066
| Hs_GenLoc_end = 49858689
| Hs_Uniprot = P15151
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Poliovirus receptor''', also known as '''PVR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAPGEF1... {November 9, 2007 3:08:21 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 3:09:05 PM PST}
- CREATED: Created new protein page: RAPGEF1 {November 9, 2007 3:09:14 PM PST}
- INFO: Beginning work on TACSTD1... {November 9, 2007 3:18:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:20:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tumor-associated calcium signal transducer 1
| HGNCid = 11529
| Symbol = TACSTD1
| AltSymbols =; CD326; CO17-1A; EGP; EGP40; Ep-CAM; GA733-2; KSA; M4S1; MIC18; MK-1; TROP1; hEGP-2
| OMIM = 185535
| ECnumber =
| Homologene = 1764
| MGIid = 106653
| GeneAtlas_image1 = PBB_GE_TACSTD1_201839_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4072
| Hs_Ensembl = ENSG00000119888
| Hs_RefseqProtein = NP_002345
| Hs_RefseqmRNA = NM_002354
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 47449954
| Hs_GenLoc_end = 47467661
| Hs_Uniprot = P16422
| Mm_EntrezGene = 17075
| Mm_Ensembl = ENSMUSG00000045394
| Mm_RefseqmRNA = NM_008532
| Mm_RefseqProtein = NP_032558
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 87545024
| Mm_GenLoc_end = 87559453
| Mm_Uniprot =
}}
}}
'''Tumor-associated calcium signal transducer 1''', also known as '''TACSTD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This 9-exon gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas.<ref>{{cite web | title = Entrez Gene: TACSTD1 tumor-associated calcium signal transducer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4072| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TBK1... {November 9, 2007 3:37:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:37:43 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = TANK-binding kinase 1
| HGNCid = 11584
| Symbol = TBK1
| AltSymbols =; FLJ11330; NAK; T2K
| OMIM = 604834
| ECnumber =
| Homologene = 22742
| MGIid = 1929658
| GeneAtlas_image1 = PBB_GE_TBK1_218520_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007249 |text = I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 29110
| Hs_Ensembl = ENSG00000183735
| Hs_RefseqProtein = NP_037386
| Hs_RefseqmRNA = NM_013254
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 63132167
| Hs_GenLoc_end = 63182153
| Hs_Uniprot = Q9UHD2
| Mm_EntrezGene = 56480
| Mm_Ensembl = ENSMUSG00000020115
| Mm_RefseqmRNA = NM_019786
| Mm_RefseqProtein = NP_062760
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 120949520
| Mm_GenLoc_end = 120989807
| Mm_Uniprot = Q3THP3
}}
}}
'''TANK-binding kinase 1''', also known as '''TBK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.<ref>{{cite web | title = Entrez Gene: TBK1 TANK-binding kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29110| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNFRSF9... {November 9, 2007 3:11:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 3:12:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tumor necrosis factor receptor superfamily, member 9
| HGNCid = 11924
| Symbol = TNFRSF9
| AltSymbols =; 4-1BB; CD137; CDw137; ILA; MGC2172
| OMIM = 602250
| ECnumber =
| Homologene = 1199
| MGIid = 1101059
| GeneAtlas_image1 = PBB_GE_TNFRSF9_207536_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TNFRSF9_211786_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3604
| Hs_Ensembl = ENSG00000049249
| Hs_RefseqProtein = NP_001552
| Hs_RefseqmRNA = NM_001561
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 7902494
| Hs_GenLoc_end = 7923513
| Hs_Uniprot = Q07011
| Mm_EntrezGene = 21942
| Mm_Ensembl = ENSMUSG00000028965
| Mm_RefseqmRNA = NM_001077508
| Mm_RefseqProtein = NP_001070976
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 149763990
| Mm_GenLoc_end = 149789893
| Mm_Uniprot = Q3U3R1
}}
}}
'''Tumor necrosis factor receptor superfamily, member 9''', also known as '''TNFRSF9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.<ref>{{cite web | title = Entrez Gene: TNFRSF9 tumor necrosis factor receptor superfamily, member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3604| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sica G, Chen L |title=Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=47 |issue= 5 |pages= 275-9 |year= 2000 |pmid= 10604232 |doi= }}
*{{cite journal | author=Schwarz H |title=Biological activities of reverse signal transduction through CD137 ligand. |journal=J. Leukoc. Biol. |volume=77 |issue= 3 |pages= 281-6 |year= 2005 |pmid= 15618293 |doi= 10.1189/jlb.0904558 }}
}}
{{refend}}
{{protein-stub}}
end log.
