#FluorescenceFriday Highlight: Showcasing High-Throughput Multi-Scale Imaging Solutions for Human and NHP Tissue. 💡 Our #Megatome Premium, together with LifeCanvas tissue preservation and clearing reagents and the #MegaSPIM light sheet imaging system, delivers a complete and robust solution. Read full blog post here: https://lnkd.in/dS8Csjfx 📸 Example below demonstrates the above solution with a marmoset brain injected with CTB-Alexa Fluor 561 and CTB-Alexa Fluor 647. The whole marmoset brain was first sectioned with #Megatome Premium into intact 1 mm thick sections. The sections were then processed with #SHIELD, clearing, index matching, and finally imaged with #MegaSPIM. Samples courtesy of Denis Matrov and the Yogita Chudasam Lab at The National Institutes of Health.
LifeCanvas Technologies Inc.
Biotechnology Research
Cambridge, Massachusetts 12,102 followers
Revolutionizing bioimaging to elevate human health.
About us
Founded out of MIT, LifeCanvas Technologies is revolutionizing bioimaging with powerful end-to-end solutions for intact tissue spatial biology. Through partnerships with leading scientific institutions, LifeCanvas is transforming biomedical research, drug discovery, personalized medicine, and disease diagnoses.
- Website
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http://www.lifecanvastech.com
External link for LifeCanvas Technologies Inc.
- Industry
- Biotechnology Research
- Company size
- 11-50 employees
- Headquarters
- Cambridge, Massachusetts
- Type
- Privately Held
- Specialties
- tissue clearing , CLARITY , SWITCH, MAP , stochastic electrotransport, immunostaining, antibody labeling , fluorescence microscopy, 3D imaging, neuroscience, microscopy, tissue processing, CRO, biotechnology, spatial biology, biomedical research, biology, biology research, drug discovery, molecular biology, histology, precision medicine, diagnostics, cancer biology, organoids, and microtomy
Locations
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Primary
1035 Cambridge St
Cambridge, Massachusetts 02141, US
Employees at LifeCanvas Technologies Inc.
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Christopher Tsang
Customer Success | Life Sciences | Emerging Technologies
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Kurt Anderson
Dynamic human resources leader who loves growing small companies to their next inflection point.
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Mingsheng Zhang
Full stack application developer, data engineer
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Brandon Hager
Director of Software Engineering and Analytics at LifeCanvas Technologies
Updates
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Happy #FluorescenceFriday! Discover the power of #MegaSPIM, our high-resolution light sheet microscope for detailed and rapid volumetric imaging. Did you know #MegaSPIM can also image uncleared thin sections with high resolution and throughput? With #MegaSPIM, it takes only 35 minutes to image an uncleared mouse brain section! 🧠 Check out this 100-µm section, stained with Iba-1, and imaged in PBS with a 15X objective. Learn more here: https://lnkd.in/eXVpBkVn #brainresearch #neuroscience #microscopy #lightsheet #neurobiology #biomedicalresearch
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🧠 Check out the video showing Beta-amyloid plaques + astrocytes in AD model mouse brain from Taconic Biosciences, imaged with #SmartSPIM. #SmartSPIM, is the light sheet microscope built for intact tissues. It provides the accuracy, speed, and flexibility you need to generate the highest quality data, making no compromises on resolution or acquisition speed. Talk to our experts to learn more: https://lnkd.in/gcerzk3b Video shows: β-amyloid plaques in magenta, astrocytes (GFAP) in cyan, in brain of 7-month-old homozygous ARTE10 male mouse from Taconic Biosciences, #Alzheimer’s disease model #16347. Tissue processed with our technologies and imaged with SmartSPIM at 15X magnification.
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🏆 Congratulations to our three #LifeCanvasTravelGrant Winners for the Society for Neuroscience Conference 2024 in Chicago. Their groundbreaking research, utilizing our advanced imaging technologies, stood out among many impressive submissions. Winners and Their Research: Shreyas M Suryanarayana from the Josh Huang Lab at Duke University Neurobiology: 🧠 Evo-devo diversification of cortical output channels. 🔬 Featuring: Clear+ clearing pipeline and #SmartSPIM light sheet microscope. Albit Caban from the Ramirez Lab at Boston University: 🧠 Prefrontal cortex arbitrates memory-guided conflict resolution 🔬 Featuring: Clear+ clearing pipeline and, #SmartSPIM light sheet microscope. Sam Reynolds from the Meng Lab at University of New England: 🧠 Whole brain mapping of activity-dependent genetically labeled neurons after corneal stimulation 🔬 Featuring: #SmartBatch+ system for active tissue clearing and labeling, and, #SmartSPIM light sheet microscope. We are incredibly proud to support these innovative researchers by featuring their abstracts at our booth and social, and a big thank you to everyone who participated – the competition had many impressive abstracts. 📣 Stay tuned for more updates and exciting opportunities!
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Happy #FluorescenceFriday! Today, we’re thrilled to showcase our video showing c-FOS labeling (green) and detected c-FOS+ cells (red) in a mouse brain, imaged with #SmartSPIM at 3.6X magnification and analyzed with #SmartAnalytics. Why c-FOS? c-FOS is a protein derived from immediate early gene expression and is recognized as a specific marker of neuronal activity throughout the mammalian brain. Through a variety of perturbations (e.g. drug treatments, external stimuli), expression levels become elevated. By detecting c-FOS+ cells throughout tissue volumes via immunolabeling, imaging, and analyses, neural activity can be visualized, mapped, and quantified throughout the brain. Our end-to-end solutions for #3DSpatialBiology are designed to streamline your research and provide you with deep insights for a variety of applications, including neural function, from sample preparation to advance data analysis. Researching the complexities of brain activity? Connect with us today! https://lnkd.in/dNCwPWsA #neuroscience #research #brainmapping #lightsheetimaging #microscopy #brain
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🔬 ✨ High-Resolution Imaging with #MegaSPIM! #MegaSPIM is setting new standards in light sheet microscopy by delivering unparalleled high-resolution volumetric imaging. Its capabilities extend across: - High-throughput imaging with exceptional detail. - Versatility for various tissue types, from thin sections and cleared thick sections to arrays of cleared whole rodent organs or organoids. - User-friendly software designed for seamless operation and streamlined post-processing. Just take a look at this remarkable image from Dr. Hongwei Dong's Lab at UCLA using #MegaSPIM for functional networking and connectome research. ➡ Want to see how #MegaSPIM can elevate your research? Learn more about MegaSPIM: https://lnkd.in/eXJKmD7m #lightsheet #3Dspatialbiology #imaging #neuroscience #research #brainresearch
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Last week, we had the incredible opportunity to support the Tissue Clearing and Light Sheet Workshop at the University of Washington. This event, hosted by the #NAPE (Neuroscience of Addiction, Pain, and Emotion) consortium, brought together passionate researchers from over a dozen labs to explore the cutting-edge realm of light sheet imaging. We were thrilled to showcase our full pipeline for #3DSpatialBiology: from sample preparation, to light sheet imaging. - #SHIELD technology for excellent tissue preservation. - #SmartBatch+ for active tissue clearing and immunolabeling. - #SmartSPIM light sheet microscope providing the accuracy, speed and flexibility for generating the highest quality data. - #SmartAnalytics2 for detailed 3D analysis. A big thank you to the organizers: Jovanna Navarrete, Kentaro Ishii, Eric Szeleny, Jingyi Chen, Charles Zhou, Lusine Eyde, and Sam A. Golden university. Your efforts made this event a success!
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We’re excited to share the recent study by Theodore Zwang from the Zwang Lab and Rachel Bennett from the Cambridge Bennet Alzheimer's Lab at Mass General Hospital and Harvard University. Their research leveraged our #MegaSPIM Light Sheet Microscope to show cerebral amyloid angiopathy pathology and tau accumulation near blood vessels in brains of individuals who have #Alzheimer’s disease. https://lnkd.in/dCqqNdqS
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Check out the video from the new research published in Science Magazine. This work was led by our founder, Kwanghun Chung, with significant contributions from Jeffrey Stirman (CTO at LifeCanvas Technologies) and three former Chung Lab members at Massachusetts Institute of Technology who are now part of LifeCanvas Technologies: Ji Wang (Director of Mechanical Products), Nicholas Evans (Senior Microscope Engineer), and Webster Guan (Principal Image Data Scientist). The paper showcases how LifeCanvas' cutting-edge technologies, including #Megatome, #SHIELD, and #MegaSPIM, are transforming the study of human organs, particularly the brain. Read full article: https://lnkd.in/duhgpzE5 ✨ At LifeCanvas Technologies, our goal is to transform tissue imaging and analysis to empower researchers to conduct thorough, integrative analyses of human and animal tissues at unmatched speed and resolution.
A suite of three innovations by an Massachusetts Institute of Technology- based team enables high-throughput imaging of human brain tissue at a full range of scales and mapping connectivity of neurons at single cell resolution. https://lnkd.in/eHRuJEKs https://lnkd.in/eHRuJEKs MIT School of Engineering MIT Brain and Cognitive Sciences MIT Chemical Engineering (ChemE) #neuroscience #brain #imaging
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Super proud of my coworkers at LifeCanvas. It’s no small feat to accomplish so much and to be published in such a prestigious journal. Looking forward to a bright future! ☀️🧠
🔬 Exciting News from LifeCanvas Technologies! We are excited to share the latest publication in Science, featuring groundbreaking research from the Chung Lab at Massachusetts Institute of Technology. This research, led by Kwanghun Chung, our founder, includes significant contributions from Jeffrey Stirman (CTO at LifeCanvas Technologies Inc.) and three former Chung Lab members who are now part of LifeCanvas Technologies Inc.: Ji Wang (Director of Mechanical Products), Nicholas Evans (Senior Microscope Engineer), and Webster Guan (Principal Image Data Scientist). 🧠 The paper showcases how LifeCanvas' cutting-edge technologies, including #MEGAtome, #SHIELD, and #MegaSPIM, are transforming the study of human organs, particularly the brain. - #SHIELD: Ensures permanent protein preservation through multiple imaging cycles. - #MEGAtome: Precision slicing for maintaining critical structural details in large biological samples. - #MegaSPIM: Captures multiscale data with high-throughput cellular resolution and adaptability for large tissue samples. These technologies have been pivotal in analyzing #Alzheimer's disease pathology in human brains, revealing detailed insights into cell distributions, neuronal structures, and synaptic connections. This holistic mapping approach opens new avenues for understanding complex brain disorders. ➡ At LifeCanvas Technologies, we’re committed to pushing the boundaries of tissue imaging and analysis. We believe this technology will significantly advance our knowledge of brain architecture and its alterations in diseases, paving the way for better diagnostics and therapies. Our goal is to empower researchers to conduct thorough, integrative analyses of human and animal brains at unmatched speed and resolution. 🔗 Full access here: https://lnkd.in/duhgpzE5
Integrated platform for multiscale molecular imaging and phenotyping of the human brain
science.org